Beyene,Alemseged(Asso. Prof.)Aynalem,Minychel Wale2024-04-232024-04-232023https://etd.aau.edu.et/handle/123456789/2801Background: Atopic dermatitis (AD) is the most common chronic skin disease in children. It is chrcaterized by dry, itchy, eczematous skin symptoms. These symptoms produce dramatic negative impact on quality of life (QoL) of patients.There is a paucity of study on patients’ QoL, the pattern of treatment practices, and factors associated with poor QoL in children with AD in Ethiopia. Objective: To assess QoL, treatment practice, symptoms control status and its associated factors among children with AD at ALERT dermatovenerology unit, Addis Ababa, Ethiopia. Method: Prospective observational study was conducted at ALERT comprehensive specialized hospital dermatovenereology unit from September 01, 2022 to February 31, 2023. Structured questionnaire and CDLQI tool were used to collect the data. Data were collected, entered and analyzed using Statistical Package for the Social Sciences (SPSS®) version 25. Descriptive statistics were used to summarize the data while multivariable binary logistic regression analysis was used to determine factors associated with QoL. P-value <0.05 was considered as statistically significant. Results: Among 403 study partciapnst (53.6% , n= 216 ) were female. The mean (+SD) age of the study participants was 8.04 (+3.40) years. The age onset of the disease in (41.7 %, n= 168) study participants was mid onset. Among study participants, the majority of them, (84.6%, n= 341) had pure AD.The duration of the disease in (76.4 %, n= 308) patients were less than to 5 years. Among study participants, the majority of them, (42.2 %, n= 170) had Sub- Acute phase, Non lessional type AD (71.7 %, n= 289), followed by Moderate (57.6 %, n= 232). Topically applied readymade medicine, antihistamine and emollient was given for (55.6 %, n = 224), (24.3 %, n= 98) and (75.8%, n=305) partcipants, respectively. The mean CDLQI was 8.42(+ 3.57) crosponding to a moderate effect. Domain of itching, dressing and sleeping was the utmost affected QoL. Majority of the study partcipants (75.7%, n=305) had localized Pruritus followed by , dry skin (70.7%, n= 285) symptoms .AD symptoms was controlled among (76.9%, n = 310) patients. Multivariabel logistic regression showed that government employed caregivers [AOR=5.5 (95% CI: [1.18, 27.61)], P=0.038; daily laborer caregivers [AOR = 16.23 (95 % CI: [1.78, 148.1)], P= 0.014 ,having moderate AD [AOR = 4.20 (95% CI: [2.25, 7.8)], P=0.001), having Allergic rhinitis comorbidities [AOR=20.6 (95% CI: [1.55,275.5)], P=0.022 and who use topically applied Tacrolimus [AOR=5.63 (CI: 1.03, 30.92)] was signifcantly associated with QoL. IV Conclusion: Emollients, topically corticosteroids, and antihistamines were the mainstay treatment. AD has significant impact on the QoL of children, mainly through Symptom and feeling , sleeping problems and dressing problems. Majority of children with AD symptoms were controlled. Factors such as Government employee, daily laborer, moderate AD , allergic rhinitis, and use of topical tacrolimus were considered to have poor QoL. Thus, widening the AD management with education and evaluating of children QoL deemed to be imprortant.en-USAtopic dermatitis (AD)Quality of Life (QoL)Child Dermatology Life Quality Index (CDLQI)All Africa LeprosyTBand rehabilitation training Center (ALERT)Ethiopia.Thesis