Tiliksew TeshomeInas Basha2025-03-202025-03-202023-10-15https://etd.aau.edu.et/handle/123456789/5197Objective: To determine the pattern of ocular manifestations in patients diagnosed with hematologic malignancies at tertiary hospital Methods: A cross-sectional observational study was done by examining all patients attending hematology unit at a tertiary hospital in Addis Ababa who were diagnosed with hematologic malignancies that was confirmed by a bone marrow biopsy or diagnosed by a hematologist. They underwent comprehensive ophthalmic evaluation. Patients with vascular diseases like hypertension, diabetes mellitus, systemic lupus, HIV/AIDS were excluded from the study. Results were analyzed using chi square test and multivariate regression models. Result: In this study 80 participants having a hematologic malignancy were involved. Almost thirty-nine percent of the study participants were in the age group of 18-40 with mean and SD of 48.7±18.5 years and the age ranges 18-90 years. The most common hematologic malignancy identified was chronic myeloid leukemia accounting for 30% (n=24) of the participants followed by multiple myeloma (16.25%) and polycythemia vera (13.75%). Nineteen (24%) of the study participants had ocular manifestation/s. The most common manifestation was cataract which affected 16.5% (n=13) of the participants. The second frequent ocular manifestation seen was Vitreous Hemorrhage 6.3%(n=5) and retinal hemorrhages 6.3%(n=5). Majority of the ocular manifestation (21.1%) occurred in those with multiple myeloma followed by chronic myeloid leukemia (15.3%). The multivariate logistic regression revealed that participant whose age >60 years had 3.2 folds increase in occurrence of ocular manifestation compared to age 18-40 years (AOR=3.2, 95%CI=1.36, 5.97) and participants who were from out of Addis Ababa were 2.7 folds increase its ocular manifestation compared to those from Addis Ababa (AOR=2.7, 95%CI=1.82, 8.96). Conclusion: In this study ocular manifestation of hematologic malignancy was commonly seen in patients with multiple myeloma (21.1%), followed by chronic myeloid leukemia (15.3%), polycythemia vera (15.8%) and acute lymphoblastic leukemia (10.5%). The finding also showed that 24% of the participants had ocular manifestation. Among those manifestations cataract accounted 16.5% (n=13), followed by Vitreous Hemorrhage (6.3%) and Retinal hemorrhage (6.3%) then corneal deposition (2.5 %). The determinate factor of ocular manifestation identified was age of >60 years (AOR=3.2, 95%CI=1.36, 5.97) and residence out of Addis Ababa (AOR=2.7, 95%CI=1.82, 8.96).en-USPatients with Hematologic MalignanciesThesis