Admasu, Wossenyeleh (B.Sc. M.Sc.)Azanaw, Mikaele2018-11-192023-11-052018-11-192023-11-052018-06http://etd.aau.edu.et/handle/123456789/14377Introduction: Postoperative pain after abdominal surgery is excruciating, due to the damage of muscles and tissues. The importance of pain relief is well-recognized but it is most often seen that pain control is inadequate. Results of previous study shows the opioid consumption is 70% after abdominal surgery. An increasing amount of evidence suggest that intraoperative intravenous lidocaine infusion can influence pain severity, postoperative analgesic requirement and decrease opoid side effects. Objective: The aim of this study was to assess analgesic effectiveness of intraoperative intravenous lidocaine infusion as part of postoperative analgesia for patients undergoing abdominal surgery under general anesthesia in Empress Zewditu Memorial Hospital. Methodology: Institutional based prospective cohort study conducted at Zewditu Memorial Hospital among 68 American Society of Anesthesiologist (ASA) class I and II, age ≥ 18 and elective abdominal patients who underwent surgery and were grouped into exsposed and controlled group based on they have given lidocaine (1mg/kg/hr) or not. Systematic random sampling was employed. Mann Whitney U test was used to compare median pain score, time to first analgesia request in minutes and total analgesia consumption between groups. Homogeneity of categorical independent variable between two exposure groups was analyzed using Chi Square or Fisher’s exact test. Box and whisker plot were used to show a median pain score differences between groups and p value < 0.05 considered as statistical significance with a power of 80%. Result: Demographic characteristics were comparable between the groups, p>0.05. Twenty four hour median VAS score (0 to 10 cm) at immediate recovery, 3rd, 6th, 12th and 24th hour showing lower median pain score, p<0.05. The median time to first analgesia request in minutes were longer (180 minutes) in exposed group compared to 45 minutes in non-exposed group (p= <0.0001). The median tramadol consumption within 24 hour is 50 mg in exposed group compared to 100 mg in non-exposed group(p<0.0001). Conclusion and recommendation: Intraoperative lidocaine infusion decreases postoperative pain score, total analgesia consumption and prolongs time to first analgesia request for abdominal surgery done under general anesthesia. Based on these we recommend use of 1 mg/kg/hr of 2% lidocaine infusion is an effect postoperative analgesia.en-USlidocaine, Pain, abdominal surgery, infusion, Visual analogue score(VAS), Zewditu memorial hospitalThesis