Melese, Eyayalem (BSc,MSc)Awoke, Yonas2020-03-232023-11-052020-03-232023-11-052019-07http://etd.aau.edu.et/handle/123456789/21212Background: Succinylcholine is a depolarizing skeletal muscle relaxant that remains the accepted standard for facilitating endotracheal intubation. This medication may cause some adverse effects in patients such as hyperkalemia, malignant hyperthermia, increased intra gastric and intracranial pressure, fasciculation during induction, and postoperative myalgia. Although postoperative myalgia are commonly encountered problem they may be very unpleasant experiences for the patient till 24–48 h after surgery . Objective: Comparison of defasciculation dose pancronium and mini-dose succinylcholine for preventing succinylcholine induced muscle fasciculations and post operative myalgia among surgical patient in menelik II referral hospital. Methodology: An institutional based prospective cohort study conducted on 96 patients undergoing elective surgery were divided in three equal groups :After pretreatment with either 0.01mg/kg defasciculating dose of pancronium as Group (n= 32) , 0.2mg/kg mini dose succinylcholine and 1ml NS group , patients were anesthetized with a 3-5mg/kg of Thiopental followed by succinylcholine 2mg/kg. Data on baseline characteristics, incidence and severity of muscle Fasciculation and post operative myalgia (after 24 hours) were collected. Results: The demographic data of patients in three groups were comparable. The total incidence of succinylcholine induced fasciculation were 17(53.1%) , 8(25%) and 30(93.8%) in pancronium, mini-dose of succinylcholine pretreatment and NS Groups respectively (p=0.000).The severity of fasciculation was reduced more in mini-dose succinylcholine compared with pancronium group (0.012) and Normal saline group (0.000).The total incidence of myalgia was 6(18.8%) 3(9.4%)and 9(28.1%) in pancronium , mini-dose of succinylcholine and Normal saline Groups respectively (p=0.158).There is no difference on the severity of myalgia between groups (p=0.161) Conclusion and recommendation: pretreatment with mini dose of succinylcholine is effectively reduced the incidence and severity of succinylcholine induced fasciculation in comparison with pancronium and Normal saline group. but there was no difference in the incidence and severity of post operative myalgia between the three groups. We recommended to use mini dose of succinylcholine as a pretreatment to reduce succinylcholine induced fasciculation.en-USDefasciculation dose pancronium , mini-dose succinylcholineThesis