Dr.Tarekegn, Getahun(Consultant internist, and endocrinologist, Assistant Professor of medicine)Asnake, Nebiat Sileshi2021-02-102023-11-052021-02-102023-11-052020-12http://etd.aau.edu.et/handle/123456789/25045Background: Pheochromocytomas are catecholamine-secreting tumors, the majority of which arise from the adrenal medulla. Untreated, they are potentially lethal; early diagnosis and treatment offer a good chance of cure. It accounts for 0.2% of patients with Hypertension in western world. Limited data exists regarding pheochromocytoma in developing world. Knowing disease characteristics and presentation in this unstudied population helps to diagnose pheochromocytoma early. Objectives: The objective of this study was to review the disease characteristics and management outcome of patients with pheochromocytoma among patients who were evaluated in Tikur Anbessa Specialized hospital, Addis Ababa Ethiopia over a 10-year period. Methodology: Institution based retrospective cross sectional study design was used and all patients with pheochromocytoma evaluated from 2010 to 2020 medical records were reviewed, pertinent data was collected and analyzed using SPSS 26. Frequency tabulation, Chi square test, bivariate and multivariate logistic regression and Pearson correlation were used to study the relationship among different variables. Results: Twenty-eight patients were included in the study, of which 43% were male and 57% female. The mean age was37 years (range 16–67). Incident of diagnosis was after the patients were symptomatic in 75% of patients and after incidental discovery of adrenal mass in 25% of patients. The median tumor size was 6 cm, and mean of 5.8±1.6cm, 30% were larger than 6 cm. 75% were located in the adrenal gland (n=21, 71% unilateral, 3.6% bilateral), and 21.4%(n=6) were extraadrenal. The most common extra adrenal site was intra-abdominal paraganglioma (n=4, 14.3%). There were 3 patients (10.7%) with malignant pheochromocytoma as suggested by imaging features and recurrence. Clinical diagnosis of pheochromocytoma associated genetic syndrome was made in 3(10.7%) patients, MEN 2a in two patients and vHL in one patient. Surgical cure rate among symptomatic pheochromocytoma patients was 93.5% (n= 15). Although No significant predictor of risk of malignancy or risk of recurrence was found in this study, the trend was towards higher risk of recurrence for patients who are male and symptomatic at the time of diagnosis with extra adrenal location of the tumor. On the other hand, being not operated was associated with increased risk having persistent symptoms (AOR: 58 P value: 0.006) and being older age at diagnosis (AOR: 0.7 P value: 0.04) was associated with decreased risk. Conclusion and recommendation: Majority of patients with pheochromocytoma are symptomatic with classic symptoms, targeted screening with goal of early detection and surgical management is recommended. Large scale study with prospective follow up is necessary to known the burden of this rarely reported potentially malignant neoplasm.en-USPheochromocytoma ,PatientsThesis