Prof.Makonnen, Eyasu(PhD, Professor of Pharmacology)Alemkere, Getachew(BPharm, MSc, Assistant Professor of clinical pharmacy)Yenesew, Asmamaw2021-10-132023-11-062021-10-132023-11-062021-07http://etd.aau.edu.et/handle/123456789/28115Patients with diabetes are at high risk of drug therapy-associated problems (DTPs), as they are exposed to multiple medications. Studies conducted on DTPs in diabetic patients in Ethiopia are, however, limited. This study was, therefore, aimed to assess the magnitude, pattern, and factors associated with DTPs among patients with type 2 diabetes at Dagimawi Menelik Hospital (DMH). A cross-sectional study was conducted among 294 patients who fulfilled the inclusion criteria. Patients were interviewed using a structured data collection format, involving retrospective medical chart review. DTPs were assessed using Cipolle‘s classification system. Descriptive data were reported using tables and figures. A multivariate logistic regression analysis was performed to identify factors associated with DTPs. A total of 448 DTPs in 193 (65.6%) patients were identified. Most commonly identified DTPs were non-compliance, 118(26.3%), need additional drug, 110(24.6%), and dosage too low 89 (19.9%). On multivariate analysis, history of hospitalization (AOR= 4.34, 95% CI: 1.21, 15.54), poor glycaemic control (AOR= 59.5 95% CI: 18.9, 188.0), presence of co-morbidity (AOR= 6.7, 95% CI: 2.4, 19.0) and diabetes complication (AOR= 4.1, 95% CI: 1.1, 15.2) were positively associated with occurrence of DTP On the other hand, physical activity (AOR= 0.2, 95% CI: 0.0, 0.7), absence of polypharmacy (≤3 drugs) (AOR= 0.1, 95% CI: 0.0, 0.6) were protective for the development of DTP. In conclusion, there was high prevalence of DTP particularly among patients with poor glycemic control, history of hospitalization, comorbidities, complications, inactivity and polypharmacy.. Further studies on the prevention and management of DTPs, therefore, need to be conducted.en-USDiabetes mellitus, drug therapy problems, factors, EthiopiaThesis