Dr.Abebe, Bezaye(MD,Assistant professor of pediatrics and child health)Dr.Pais, Priy(MD,Associate professor, Pediatric Neurologist)Chekol, Getasew2022-02-142023-11-052022-02-142023-11-052021-11http://etd.aau.edu.et/handle/123456789/30049Background Children with chronic kidney disease face lifelong increases in morbidity, mortality, and decreased quality of life. As most of other chronic illnesses, CKD has hard impact on ill children's and care givers life style, peer relationship, pain interference and social functioning moreover CKD has impact on intellectual functions and behavioral characteristics including anxiety and depression. Objective- To assess health related quality of life of children with CKD as well as their caregivers‟ perception on their Childs performance and to determine the factors that adversely affect it. Methods and material: A cross-sectional analytical study conducted using a pre coded, pretested structured questionnaire including PedsQoL TM 4.0 scale score generic core and family impact module. Data obtained for demographic and clinical parameters of children and for each domain of generic core and family impact module and data was analyzed using IBM SPSS version 26. Results- 105 children with CKD aged 2-18 years, 61(58.1%) males and 44(41.9%) females were included in this study. Among the child self reported domains of generic core scale, child‟s „school performance‟ was most affected with mean of 74.91 (SD±22.29) followed with child „physical performance‟ 77.6±26.41. In the family impact module domains with mean also, the most affected being „school performance‟ with 75 (SD±19.89) followed with „physical functioning‟ with 78.13 (SD±24.96). Recommendation: „School performance‟ and „physical functioning‟ were the most affected domains in child generic scale and family impact modules. Optimal care requires attention not only to medical management, but also to an assessment of health related Quality of Life factors, that may help promote pediatric CKD patient‟s health like Implementation of a standardized tool and Multidisciplinary approach in addressing HRQoL in all CKD patients on follow up.en-USKidney disease ,Quality of life ,ChildrenThesis