Temesgen,Busha(PhD)Teshome, Dawit( M.Sc)Getachew,Fikadu2024-04-232024-04-232023https://etd.aau.edu.et/handle/123456789/2798Introduction: Curing and prevention of diseases are challenging circumstances for health-care professionals. Immunization has been identified as one of the most cost-effective health interventions in preventing diseases. Too high or too low temperature makes vaccines loss their effectiveness and potency irreversibly and permanently. So, good management and handling of vaccines is necessary. Storage area, storage equipment, transportation protocols, transportation systems, the working staff, etc. are some of the factors that may affect the cold chain and logistics of vaccines at different settings. Objectives: The objective of this study is to assess the factors affecting the vaccines cold chain management practices. Methods: A mixed method was implemented to identify the factors affecting the vaccines cold chain management practices at Sebeta town and Sebeta Hawas Woreda from Aug 2022 to Oct 2022 G.C. and Census method and Purposive sampling techniques were used. Result: Age of the respondents fall in the range of 24 to 48 years with a mean age and standard deviation (SD) of 25.95±3.81. All the respondents know that freezing and heat affect the potency of vaccines. 95.8% of the respondents know that OPV is the most heat sensitive vaccine whereas 97.9% of the respondents know that a contingency plan for power supply is important. Labeling vaccines with time and date of reconstitution is known by 95.8% of the vaccines handlers. 10.5% of the vaccinators and the vaccine handlers do not know that keeping foods and other items with vaccines affect quality of vaccines. Information management system, man power availability and storage facilities are highly significant factors that affect the vaccines cold chain management practice indicating the R square from the regression is 0.586. Conclusion: Despite high percentage of good knowledge and positive attitude, poor availability and adherence to cold chain guideline, insufficient number of man power, insufficient storage space in some health centers and low coverage of EPI trainings are determinant factors that directly or indirectly affect the vaccines cold chain management practice in the study area.en-USVaccinesCold ChainHealth facilitiesImmunization ProgramsThesis