Negash ShiferawHaillu SofanitTerefe Daniel2022-01-272025-01-082022-01-272025-01-082021-08https://etd.aau.edu.et/handle/123456789/29743Background: Cervical cancer is the second most prevalent malignancy in Ethiopia associatedwith high mortality and morbidity. Nonetheless, few efforts have been made to assess thepatients’ HRQOL, and its predictive factors in Ethiopia. Objective: To describe Health Related Quality of Life, its predictive factors of cervical cancerpatients in Tikur Anbessa Specialized Hospital and Saint Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia. Methods: An institutional based cross-sectional study was conducted in Tikur Anbessa Specialized Hospital and Saint Paul’s Hospital Millennium Medical College, from Feb to June,2021G.C. A total of 264 cervical cancer patients were interviewed using the Amharic version of European Organization for Research and Treatment of Cancer module (EORTC QLQ-C30), andcervical cancer module (EORTC QLQ-CX24) .The Amharic versions of bothinstruments werepreviously validated .The data was analyzed using SPSS version 25 and Microsoft Office Excel2010. ANOVA and stepwise binary and multivariable logistic regression were employed todetermine mean difference and significant associations. Results: The mean Global quality of life (GQOL) was (mean± SD =42.57± 23.31) and with theleast affected function being physical functioning (mean± SD =76.39± 23.24) and highest socialfunction (mean± SD =50.40± 32.19). For the symptom scales, the financial difficulty had the highest mean of (mean± SD =57.83 ±35.34) and with the exception of diarrhea (mean± SD=20.08± 29.87) and dyspnea (mean± SD= 22.89± 29.87), all the other items indicated moderate to high symptoms. The EORTC QLQ-CX24 symptom scales the least affected score was on Lymph adenoma (mean± SD =27.71±37.11) and highest affected score was for sexual worry(mean± SD= 51.81+32.197). As stage increases there was a statistically significant reduction in GQOL (p = 0.005) .Age, educational status and monthly income has association with GQOL.Being in the age group <40years affects 2.12 times the GQOL compared to the other variables(AOR =2.12, 95%CI =0.23-18.90). The patients monthly income <600ETB affects the GQOL 1.7times (AOR=1.74, 95% CI = 0.34-8.93). Participants affected body image and feeling of lymph adenoma was the only two variables which had significant association with GQOL. Once sense of body image affected 1.88 times (AOR=1.88, 95%CI=0.42-8.45) the GQOL and 1.39 times(AOR=1.39, 95%CI=0.51-3.81) if affected feeling of lymph adenoma. Conclusions: GQOL, physical function, role function, cognitive functions, financial difficulties,insomnia and fatigue were the most affected however social function, dyspnea and diarrhea wereless affected components of HRQOL of cervical cancer patients. Age , marital status, educational status, occupational status ,monthly income , stage of the disease ,time since diagnosis andplanned type of treatment were some of the different socio demographic and medical factors which were associated with health related quality of life of cervical cancer patients.en-USCervical cancer, Health related quality of life, HRQOL, EORTC QLQ-C30, EORTCQLQ-CX24, EthiopiaThesis