Dr.Kebede, Eskinder (Associate Professor and Consultant Obstetrician and Gynecologist, Reproductive endocrinology and minimal access surgery subspecialist, AAU)Dr.Bedada, Abera(Assistant Professor and Obstetrician and Gynecologist, AAU)Matewos, Seblewongel2022-01-122025-01-082022-01-122025-01-082021-09https://etd.aau.edu.et/handle/123456789/29501Background: Infertility is a global public health issue affecting approximately 8 to 12% of couples worldwide, with 9% of the global average. In Ethiopia, according to the DHS data, the prevalence of primary and secondary infertility in 2005 was 3.3% 4.6% respectively. The prevalence differs by place of residence, marital status, age of respondent, age at first marriage, and number of unions. The causes of infertility are various, including socioeconomic factors, lifestyle, reproductive history, and childbearing status. In developing societies, childlessness is often highly stigmatized and leads to profound social suffering for infertile women; however, most infertile people in the developing world have virtually no access to effective treatment. Objective: To identify the determinants of infertility among married women attending an infertility clinic at two teaching hospitals in Addis Ababa, Ethiopia Methods: An institution-based unmatched case-control study was conducted at two teaching hospitals, gynecology and obstetrics infertility clinics in Addis Ababa. A total of 234 women was included in the study. Study participants was selected using a systematic random sampling technique for both cases and controls. Data was collected using a pre-tested interviewer-administered structured questionnaire by trained data collectors. The data was checked for completeness, cleaned, entered, and analyzed using SPSS version 24.0. Results: Approximately 52.6% (41 females) of the samples had secondary infertility, while 47.4% had primary infertility (37 females). After logistic regression was made, the determinants of infertility identified were age of women (AOR=4.914; 95%CI: 2.3.60, 10.230), menstrual regularity (AOR= 2.859; 95%CI: 1.338, 6.109), history of TB infection (AOR = 8.518; 95%CI: 1.554, 46.702) and frequency of sexual intercourse (AOR= 5.304; 95%CI: (2.046, 13.749) Conclusion and recommendations: Secondary infertility accounts for 52.6% of the infertile women, while primary infertility accounts for 47.4% of them. Age of women, menstrual regularity, History of TB infection and frequency of sexual intercourse were found to be determinants of female infertility.en-USInfertility,married womenThesis