Bitew AdaneW/Senbet ZerihunGaredew Andualem2021-11-292023-11-062021-11-292023-11-062021-06http://etd.aau.edu.et/handle/123456789/29005Background: Managing the burn wound is necessary to heal the wound early but the infectedone not only needs appropriate management of burn therapy, in addition to that, doing culture forthe potential bacteria and their antimicrobial susceptibility pattern necessary. Furthermore Largewound surface, impaired immune systems, and broad-spectrum antibiotic therapy contribute tothe growth of opportunistic fungal species. Mycosis in burns is likely to be underestimated. Objectives: To determine the magnitude of bacterial and fungal infections and the irantimicrobial susceptibility pattern of burn patients at Yekatit12 and AABET Hospital, AddisAbaba, 2021. Methods: A cross-sectional study was conducted in Y12HMC and AABET hospital fromJanuary to June 2021. Burn Wound swab specimen was collected using sterile cotton swab andprocessed and analyzed for bacteriological and fungal culture medias like Potato dexterous agar,Chrome agar, Blood agar, MacConkey agar, Biochemical test and AST. The data was analyzedusing SPSS version 25. Results: 240 burn patients were included in the study a total of 154(64.2%) bacterial pathogenswere recovered. Among the isolated 154 (64.2%) bacteria 110 (71.4 %) were gram-positive and44 (28.5 %) gram-negative bacteria. From gram-positive bacteria, predominant bacteria isolateswere CoNs 55 (22.9 %), followed by S.aureus 54 (22.5%) while gram Negative bacteria isolatedthe most predominant bacteria were Pseudomonas aeruginosa 17(7.1%)from 66 (27.5%).Fungus isolation 38 (57.5%) were yeast and 28 (42.2 %) mold .The susceptibility patterns ofisolates 60% of resistance to the antibiotics tested. Klebsiella species demonstrated high level ofresistance to Ampicilin and ceftazidime each 5(100%), Tobramycin, ciprofloxacin andgentamicin each 3(60%). Amikacin was relatively effective against 23(95.8%) of the Klebsiellaspecies. CONCULUSION: The wounds were contaminated with various types of bacteria. This might bea reflection of inappropriate use of antibiotics. The presence of MDR in the wound may be afactor for persisted infection. Some of the participants in the study area had a positive fungalresult. It is not contemptible it an alarming finding that needs more focus and follow-up on thefungal infection.en-USMultidrug resistance, antimicrobial susceptibility pattern.Thesis