Tamir ZemenuAlemu RahelYhdego Kidane2021-11-122023-11-062021-11-122023-11-062021-09http://etd.aau.edu.et/handle/123456789/28621Background: Diabetes mellitus is a non-communicable disease that has a high prevalenceworldwide. Altered level of many hematological and biochemical parameters have beenobserved in patients with diabetes. Although type ӀӀ diabetes mellites alters hematological andbiochemical parameters, so far, very little work has been done in Ethiopia linking hematologicalparameters and biochemical markers with type ӀӀ diabetes mellites patients. Objective: To assess alteration of hematological and biochemical parameters in type ӀӀ diabetesmellitus patients attending Aksum St. Marry Hospital, Aksum,December 2019-April 2020 Method: comparative cross-sectional study was conducted from December 2019 to April 2020Aksum St. Marry Hospital, Aksum, Northern Ethiopia. A total of 168 participants were enrolledusing convenient sampling method. Socio-demographic, behavioral and physical measurementdata were collected. Complete blood count was performed by sysmex KX-21N hematologyanalyzer. The biochemical parameters were analyzed by using BE200. Data was analyzed usingSPSS 23. Student independent t-test and person’s correlation statistical method employed toanalyze data. P values < 0.05 was regarded as statistically significant at 95% confidence level. Result: Among the hematological parameters WBC count, neutrophil count, lymphocytes count,platelet count, MPV significantly increased. Similarly, RBC count, hemoglobin and PCVshowed significant decrease in T2DM patients compared to controls. With regard to biochemicalparameters ALT, AST, ALP, Creatinine and urea showed significantly increasing in T2DMpatients when compared to controls. Regarding correlation, WBC with BMI and MCHC withFBS had positive correlations. Conclusion: There is alteration in total WBC, neutrophil, lymphocyte, eosinophil, basophil,RBC, hemoglobin and PCV. Also, from biochemical parameters ALT, AST, ALP, urea andcreatinine altered in diabetes patients compared with control group.en-USType ӀӀ diabetes mellitus, hematological parameters, biochemical parameters, hyperglycemia, study areaThesis