Sahlu WondimuBamlack Shewandagn2025-03-202025-03-202024-12-13https://etd.aau.edu.et/handle/123456789/5180Background: Gallstone disease ranks among the most prevalent surgical conditions, with cholecystectomy being the primary treatment for gallstones. Post-cholecystectomy syndrome (PCS) refers to a variety of symptoms that occur in patients following gallbladder removal. Objectives: This study seeks to assess and evaluate the occurrence and characteristics of post-cholecystectomy syndrome at Zewditu Memorial General Hospital over a one-year period, from January 1, 2023, to December 31, 2023. Patients and Methods: A retrospective cross-sectional study was conducted over one year, involving 210 patients who underwent either open or laparoscopic cholecystectomy at Zewditu Memorial General Hospital between January 1, 2023, and December 31, 2023. Results: The study included patients with a mean age of 40.19 ± 12 years and a median age of 37 years, with the majority (38.6%) in the 30–39 age group. Females constituted 86.7% (182) of the participants. Abdominal pain was reported by 92.8%, and 72.4% experienced fatty meal intolerance. Post-cholecystectomy syndrome (PCS), characterized by persistent biliary colic or right upper quadrant pain along with various gastrointestinal symptoms, was observed in 33% of patients. Among those with PCS, 25.7% reported persistent abdominal pain. Preoperative jaundice and advancing age were linked to an increased risk of PCS. Conclusions: PCS is a prevalent condition at Zewditu Memorial General Hospital, often overlooked in its impact. Adopting advanced diagnostic methods, conducting comprehensive preoperative assessments, ensuring meticulous surgical planning, and maintaining precision during procedures can greatly reduce its occurrence, leading to improved patient outcomes and reduced healthcare costs.en-USAnalysis of post cholecystectomyThesis