Prof. Hailu, AsratDr. Woldeamanuel, YimtubezenashAbebe, Mekdelawit2021-11-142023-11-062021-11-142023-11-062021-08http://etd.aau.edu.et/handle/123456789/28642INTRODUCTION:Drug Resistant Tuberculosis is defined as tuberculosis that does not respond to antituberculosis agent. Data on the outcome of MDR/RR-TB and associated factors is highly needed to evaluate the efficiencies of the MDR/ RR-TB treatment program. However, The treatment outcome of MDR/RR-TB at St. Peter Specialized Hospital is not studied. OBJECTIVE: To assess treatment outcomes of MDR/RR-TB and its associated factors at St. Peter Specialized Hospital, Addis Ababa, Ethiopia from 2015 to 2020. METHODS: A retrospective study was conducted among patients treated for drug-resistant tuberculosis from January 2015 - December 2020 at St. Peter specialized hospital. This study included 335 patients treated for multidrug resistant or rifampicine-resistant tuberculosis. The main outcome variable was overall MDR/RR-TB treatment outcome classified as successful and poor. Data were collected by trained nurses. Data entry and analysis were performed using Excel and SPSS. The relationship between MDR/RR-TB treatment outcome and associated factors was evaluated by fitting logistic regression. The final multivariable logistic regression model was a good fit for the data and had no multicollinearity issue. Statistical significance was considered at p<0.05. RESULTS: Treatment success was achieved in 71.3% of the patients. The adjusted odds of poor treatment outcome were twice higher in those who had a habit of frequent alcohol drinking (AOR=2.07, p=0.039). Likewise, the adjusted odds of poor treatment outcome was more than 2folds higher in patients who had a positive result for HIV test. Concerning mortality, the likelihood of death was found to increase by 5% as age advances by one year (AOR=1.05, p<0.001). In addition, the risk of death was more than 3-fold higher among MDR/RR-TB patients co-infected with HIV (AOR=3.81, p<0.001). CONCLUSION: In this study, the overall treatment success was consistent with studies carried out in different regions of Ethiopia. Again, a higher danger of poor treatment outcome and death was observed among people who drink alcohol, co-infected with HIV/AIDS, and the elderly.Patents with MDR/RR-TB patients, use alcohol and are co-infected with HIV/AIDS should be given greater attention during therapy. More studies should be done to generate data on the factors affecting the treatment of MDR/RR-TB patients to improve the outcome of treatment. INTRODUCTION:Drug Resistant Tuberculosis is defined as tuberculosis that does not respond to antituberculosis agent. Data on the outcome of MDR/RR-TB and associated factors is highly needed to evaluate the efficiencies of the MDR/ RR-TB treatment program. However, The treatment outcome of MDR/RR-TB at St. Peter Specialized Hospital is not studied. OBJECTIVE: To assess treatment outcomes of MDR/RR-TB and its associated factors at St. Peter Specialized Hospital, Addis Ababa, Ethiopia from 2015 to 2020. METHODS: A retrospective study was conducted among patients treated for drug-resistant tuberculosis from January 2015 - December 2020 at St. Peter specialized hospital. This study included 335 patients treated for multidrug resistant or rifampicine-resistant tuberculosis. The main outcome variable was overall MDR/RR-TB treatment outcome classified as successful and poor. Data were collected by trained nurses. Data entry and analysis were performed using Excel and SPSS. The relationship between MDR/RR-TB treatment outcome and associated factors was evaluated by fitting logistic regression. The final multivariable logistic regression model was a good fit for the data and had no multicollinearity issue. Statistical significance was considered at p<0.05. RESULTS: Treatment success was achieved in 71.3% of the patients. The adjusted odds of poor treatment outcome were twice higher in those who had a habit of frequent alcohol drinking (AOR=2.07, p=0.039). Likewise, the adjusted odds of poor treatment outcome was more than 2folds higher in patients who had a positive result for HIV test. Concerning mortality, the likelihood of death was found to increase by 5% as age advances by one year (AOR=1.05, p<0.001). In addition, the risk of death was more than 3-fold higher among MDR/RR-TB patients co-infected with HIV (AOR=3.81, p<0.001). CONCLUSION: In this study, the overall treatment success was consistent with studies carried out in different regions of Ethiopia. Again, a higher danger of poor treatment outcome and death was observed among people who drink alcohol, co-infected with HIV/AIDS, and the elderly.Patents with MDR/RR-TB patients, use alcohol and are co-infected with HIV/AIDS should be given greater attention during therapy. More studies should be done to generate data on the factors affecting the treatment of MDR/RR-TB patients to improve the outcome of treatment.en-USMDR-TB, RR-TB ,Tuberculosis, Drug Resistance, OutcomeThesis