Temesgen BelaynehFozia jemal2026-11-062026-11-062026-09-30https://etd.aau.edu.et/handle/123456789/9394This study explored the factors influencing patients' intentions to adopt telepharmacy services in selected public hospitals in Addis Ababa, Ethiopia. The study is conducted in three major public hospitals. The research utilized descriptive and explanatory design. Quantitative approach was used to collect data from 384 randomly chosen patients in the selected hospital. Data collection involved structured self-administered questionnaire that utilized a five-point Likert scale. The analysis both descriptive and inferential statistical techniques in SPSS 27. The results revealed a strong positive correlation between perceived usefulness and the intention to adopt telepharmacy services (r = 0.585, p = 0.000), indicating that increased perceptions of usefulness enhance adoption intentions. But, perceived ease of use shows a significant negative correlation (r = -0.607, p = 0.000) showing that difficulties in navigating telepharmacy services deter adoption. Perceived cost also show strong positive correlation with adoption intentions (r = 0.592, p = 0.000), implying that cost-effectiveness influences patients' willingness to adopt these services. Trust in telepharmacy is positively correlated with adoption intentions (r = 0.649, p = 0.000), but, perceived privacy is negatively correlated with adoption intentions (r = -0.614, p = 0.000), indicating that privacy concerns may hinder adoption. The regression model indicates that the predictors collectively explain approximately 59.6% of the variability in adoption intention (R² = 0.596, F = 104.726, p = 0.000). Among the predictors, trust in telepharmacy services is the most influential (beta = 0.235, p = 0.000), indicating that higher trust levels results in greater adoption intention. Perceived cost (beta = 0.196, p = 0.000) and perceived usefulness (beta = 0.152, p = 0.001) also have positive impact on adoption. But, perceived privacy (beta = -0.233, p = 0.000) and perceived ease of use shows a negative relationship with adoption intentions (beta = -0.157, p = 0.001) showing that concerns in the privacy issue and ease of use challenge the adoption intention. To enhance the adoption of telepharmacy services, healthcare providers should prioritize the implementation of strong privacy protection measures and design user-friendly interfacesen-USThesis