Matiwos Ensermu (PhD)Meron Kifle2025-08-022025-08-022024-06https://etd.aau.edu.et/handle/123456789/6009Expired pharmaceuticals pose a threat to the health care system and the environment. Moreover, expiry of Human Immunodeficiency Virus (HIV AIDS), Tuberculosis (TB) and Family Planning (FP) pharmaceuticals might lead to loss of resources in resource-limited countries like Ethiopia where pharmaceuticals for these programs is expensive. The objective of the study was to assess the factors that contributes to the expiry of HIV, TB and FP pharmaceuticals in the case of public health facilities in Addis Ababa, Ethiopia. A facility-based descriptive cross-sectional study with mixed method study design was followed to identify factors contributing expiry of pharmaceuticals for HIV AIDS, TB. Quantitative data was collected from health centers pharmacy on service related HIV, TB and FP treatment and services. On the other hand, qualitative data was collected from selected pharmacy heads of health facilities, selected sub cities of, Addis Ababa city administration health Bureau and Addis Ababa hubs of Ethiopian pharmaceuticals supply agency (EPSA). All health facilities included in the study were encountered expiry of pharmaceutical used for HIV within the previous one-year period. Significant level of expiry of pharmaceuticals used for HIV, TB and FP treatment was observed. In HIV pharmaceuticals, 42.7% of health facilities encountered expired TDF/3TC/EFV 1000 mg, 32.3% for RH 150/75 mg and 43.8 % for combined oral contraceptive tablet. Regression analysis result showed that improper forecasting and quantification is significant factors contributing for expiry of pharmaceuticals used for HIV, TB and FP at 95% level of confidence (p=0.02). The total monetary value of expired pharmaceutical used for HIV, TB and FP in the studied health facilities in Ethiopian Fiscal year of 2012 was close to 4,228,064 ETB. Average pharmaceuticals expiry rate was found to be 3.73%. Provision of training on regimen change on HIV, TB and FP treatment and integration of services with program managers are important to reduce expiry of pharmaceuticals. Keywords: Expiry of Pharmaceuticals, HIV, TB, FP, Addis Ababa, Health Facultiesen-USThesis