Daniel BisratTseganesh Abate2026-06-222026-06-222025-12-10https://etd.aau.edu.et/handle/123456789/8406Microbial diseases are among the leading causes of mortality and morbidity worldwide. The rise of antimicrobial resistance has become a significant challenge, as microorganisms have developed resistance to many existing drugs. Therefore, the search for new antimicrobials is critically important. Schiff bases (SB) and their derivatives exhibit a wide range of biological activities, including antimicrobial, anti-inflammatory, antimalarial, anticancer, and antioxidant effects, among others. Camphor (1) is a terpenoid (1, 7, 7-trimethylbicyclo [2.2.1]-2-heptanone), exists in two enantiomeric forms (1S)-m (-) is a synthetic camphor and (1R)-(+) is a natural camphor.en-USR-camphorSchiff basessynthesisantimicrobial activitymolecular dockingADMETThesis