Luce,Richard( DVM, MPH)Addissie,Adamu (MD, MPH, MA)Beyene,Zayeda2025-08-122025-08-122011-02https://etd.aau.edu.et/handle/123456789/6453Background: Malaria is a major cause of mortality and morbidity in Ethiopia. The disease is distributed in most parts of the country including Tigray. In April 2009 surveillance information and notification to the Regional Health Bureau suggested an increase in the number of malaria cases in one district. An investigation was conducted to describe the epidemiology of the outbreak and develop recommendations and guidance to improve control efforts. Methods: Secondary data was collected from logbooks in the district health office and health centre, entered into an electronic database and analyzed was using Excel. Results: 1775 suspected malaria cases and 1 death were identified between April 22 and May 11. Cases were reported from 8 villages; 930 (52.3%) were male, 685 (39%) were between 15 and 44 years of age. Rapid diagnostic tests were performed on 854 blood samples; 543 (64%) were positive for Plasmodium falciparum. The highest attack rate (AR) occurred in the villages of Asteleke (AR 47.4%; 609/1285) and Tseberek (AR 33.6%; 390/1160). Mass febrile treatment with Co-Artem was undertaken in the district. Distribution of insecticide treated nets (ITNs) had last occurred in 2005. Conclusion: A large outbreak of Plasmodium falciparum was confirmed; however, there was an extended delay in response and investigation activities. ITNs were not in use and increased frequency of distribution is necessary. Notification procedures must be improved to decrease delays in notification and facilitate earlier response activities.en-USMalaria OutbreaksEthiopiaThesis