Mekonnen, Hussen(BSc, MPH, PhD)Alemu, Tsion(BSC, MSc)Tessema, Mohammed2020-12-222023-11-062020-12-222023-11-062020-07http://etd.aau.edu.et/handle/123456789/24245Background: Neonatal Jaundice is the most common clinical problems. Globally, every year about 1.1 million babies develop it and the vast majority were in sub-Saharan Africa and South Asia, and also it occurs frequently in newborn neonates in the first weeks of life.. Objective:-The aim of this study was to assess Magnitude and Determinants of Neonatal jaundice Among Neonates admitted to Neonatal Intensive Care Unit (NICU) at Dessie Town Public Hospital from March 30 April 30 /2020. Method: A hospital-based cross-sectional study design was conducted and systematic random sampling techniques were employed. A total of 218 samples were drowning proportionally from the study hospitals.The Data was collected by prepared structured and pretested interviewer guided questionnaire and Checklist and the instrument tool was Adopted and modified after review different literature. Data were cleaned manually, coded, and entered into Epi-Data version3.1 and Analyzed by SPSS version 24 statistical software. Bivariate and multivariate logistic regration Analyses were employed to identify associated factors for neonatal jaundice. After bivariate Regression analysis a variable with P value less than 0.05 were included in multivariable logistic regression analysis. Adjusted odds ratio along with 95% CI was calculated to see the strength of association factors, and also if less than 0.05 was taken as a level of statistical significance. Result: A total of 209 mothers/ neonate’s pairs participated in the study constituting responcel;’ rate of 96%.The prevalence of neonatal jaundice was found to be 62(28.4%).Being Neonatal Sepsis [(AOR=3.82(95%CI=1.67,8.09)], Prematurity< 37weeks [AOR=3.92, 95%CI=1.89,9.11)] LowAPGARscore[AOR8..36,95%CI=1.34,39.65)],ABOincompatibility[AOR=6.94(95%CI=1.9 7,24.42)],Prolongedlabor[AOR=3.69(95%CI=1.05,12.94)]were found to be predictor of neonatal jaundice. Conclusion and Recommendation:- The prevalence of neonatal jaundice in this study was high. With regard to this high NNJ prevalence, there is need for health care providers in Dessie town public hospitals to put more emphasis on neonatal sepsis and ABO incompatibility all women tested early as possible during ANC follow up and if women blood group O should be always considered ABO setup and also Professionals who are working in NICUs should Adhere to aseptic technigues while carying and conducting neonatal invasive procedure.en-USNeonatal Jaundice, Magnitude, Determinants, Desire Town, North East EthiopiaThesis