Admassie Shimelis (PhD)Hunde Tadele2018-06-252023-11-092018-06-252023-11-092011-06http://etd.aau.edu.et/handle/12345678/3019In this study reliable and simple electrochemical method has been proposed for the simultaneous determination of paracetamol and para-amonophenol in pharmaceutical formulations. The oxidation and reduction peak potentials in of APAP at PEDOT/GC occurred at 381 and 353.65 mV vs. Ag/AgCl, respectively at pH 7.0, while those for PAP at PEDOT/GC appeared at 127 mV and 92 mV, respectively. In comparison to bare glassy carbon, the apparent reversibility and potential shift of the electrochemical reactions of APAP and PAP were significantly improved at PEDOT/GC. A peak separation of about 257.48 mV was observed while running the differential pulse voltammogram of APAP and PAP. This allows for the simultaneous determination of APAP and PAP in tablets. The linear range were found to be 1-100 μM for APAP and 4-320 μM for PAP with the detection limits of 0.4048 μM and 1.1880 μM (calculated by 3σ/m) respectively. Key words: Poly (3,4-ethylenedioxythiophene), modified glassy carbon electrode, paracetamol and para-aminophenolenPoly (3,4-ethylenedioxythiophene)modified glassy carbon electrodeparacetamol and para-aminophenolThesis