Niguse TadeleHiwot Desyalew2025-08-122025-08-122024-05-23https://etd.aau.edu.et/handle/123456789/6415Background: COVID-19 posed a serious threat to the world and presented more than 200 governments with difficult decisions. A significant percentage of hospitalized COVID-19 patients had a lower left ventricular ejection fraction. The focus of disease reporting has shifted primarily to the number of cases and deaths associated with the COVID-19 pandemic. Objective: This study aimed to identify long-term cardiovascular outcomes of COVID-19 among patients who were admitted to COVID-19 Centers of public hospitals in Addis Ababa, Ethiopia. Materials and Methods: A retrospective cohort study design was employed by reviewing records of adult patients with confirmed COVID-19 (cases) and pneumonia (controls) admitted in COVID-19 centers of Tikur Anbessa Specialized Hospital (TASH) and St. Paul Hospital Millennium Medical College (SPHMMC), from 01 June 2020, up to 01 June 2022. To lessen the impact of confounding variables, the study matched the two groups at a 1:1 ratio using greedy nearest neighbor matching for age at index, sex, lifestyle-related proxy variables (such as BMI and smoking), and comorbidities. Results: The study findings revealed that COVID-19 patients exhibit heightened risks across a spectrum of cardiovascular conditions. The incidence of stroke was notably higher in the non-COVID-19 group (37.93%) compared to the COVID-19 group (23.38%), with a hazard ratio (HR) of 1.28 (95% CI: 1.66-2.43), indicating a significantly increased risk of stroke among non-COVID-19 patients. Similarly, transient ischemic attack (TIA) was observed in 3.90% of the COVID-19 group and 4.60% of the non-COVID-19 group, with a hazard ratio of 1.11 (95% CI: 1.44-3.21, p = 0.001), showing a significant association with non-COVID-19. Conclusion: In conclusion, this retrospective cohort study reveals significant cardiovascular adverse outcomes among non-COVID-19 patients compared to a matched cohort of non COVID-19 patients in public hospitals in Addis Ababa, Ethiopia. Therefore, there should be regular and comprehensive cardiovascular assessments for COVID-19 survivors, focusing on the early detection and management of adverse cardiovascular outcomes like arrhythmias, inflammatory heart diseases, and ischemic heart diseases KEYWORDS: COVID-19, Cardiovascular Outcomes, TASH, SPHMMC, Ethiopiaen-USCOVID-19 Cardiovascular Outcomes TASH SPHMMC EthiopiaThesis