Gela, Debela(Assist. Prof.)Bizuwork, Ketema (PhD fellow)Gezahegn, Meketa2021-11-162023-11-052021-11-162023-11-052021-05http://etd.aau.edu.et/handle/123456789/28699Background even though worldwide studies explored the spiritual and religious practice can help the effect patients fine-tune the effect of cancer, little is known about spirituality wellbeing in Ethiopia, therefore this study is important to assess the spirituality and associated factor among cancer patients in Addis Ababa, Ethiopia. Objective: To assess the spirituality wellbeing and associated factors among cancer patients in Tikur Anebessa specialized hospital, Addis Ababa, Ethiopia. Methods: Institution-based cross-sectional study was conducted among cancer patients attending Tikur Anebessa specialized hospital (TASH) with oncology units in Addis Ababa from January 8 to March 8, 2021. The total sample size was 385 participants selected by the simple random sampling method. Data were entered into Epi-data version 4.6.and exported to SPSS version 25.and were checked none response rate of 10%, the actual sample size for missing values. Data were cleaned. Descriptive statistics such as frequency and percentages were done to describe and displayed in tables, graphs, and charts. Bivariate and multivariate analysis was carried out to see the association between independent and the out came variable. Significant factors were identified based on R-square include in 95% confidence level at P-value less than 0.05. Result: 422 cancer patients were included in the study. Which gave response rate was 385 (91.3%), seventy six (19.74%) participants had good spirituality well-being, 207(53.8%) participant were female, factor Sex of respondents (AOR=1.12 (CI=108.3.07)religioneducation (AOR=2.01(95%CI= 1.12,2.92), educationstatus (AOR=4. 03 (93% CI= 1.73,9.35) and comorbidity (AOR=1.32 (95% CI=1.08,2.65) significantly associated with spirituality well-being of cancer patients with p-value less than 0.05. Conclusion: In this study factor that was the sex of respondents, the educational status of respondents, those respondents having comorbidity, and respondents having religious education were significant associated with spiritual wellbeing. Recommendation: to maintain spiritual wellbeing focuses on religious education and focus on the prevention of chronic disease to tackle the comorbidity disease that increases the level of attitude cancer and improves their quality of life.en-USCancer, Factors, Spirituality, Addis Ababa, EthiopiaThesis