Heyria HusseinAndualem WubetieLemlem BezaKamil Ababor2026-06-222026-06-222025-06-29https://etd.aau.edu.et/handle/123456789/8317Background: Acute poisoning, an adverse health effect that emerges within 24 hours of exposure to a toxic substance, is a significant public health problem worldwide. Its impact is particularly severe in low- and middle-income countries, including Ethiopia. However, the full extent and severity of this problem in Ethiopia remains largely unexplored, highlighting the crucial need for further research and understanding in this area. Objective: To assess treatment outcome and associated factors of acute poisoning cases at the Emergency Department of Worabe Comprehensive Specialized Hospital, 2025 Methods: A hospital-based retrospective cross-sectional study was conducted for acute poisoning patients treated from February 1, 2022 to January 31, 2025 and data was collected from 20 March to 24 April 2025. All acutely poisoned patients meeting inclusion criteria during the three-year window were selected by census. Medical record numbers were retrieved from ED logbook and a total of 206 completed charts were reviewed using a pre-tested checklist. Collected data were entered in Epi-Data 4.6 and analyzed with SPSS 26. Binary logistic and multivariate model were used to asses factors associated with treatment outcome. Variables associated at p< 0.05 were taken as significantly associated. Result: Total of 206 patient‟s record was reviewed, and the mean age was 25. Majority 113(54.9 %) were females and 131(63.6%) resided in rural areas. Intentional ingestion of pesticides accounted for 117(56.8%) of cases. Fewer than half 94(45.6%) reached the hospital within one hour. Overall survival rate was 182(88.3%), and mortality rate 24(11.7%). Delayed presentation (>1 h) (AOR=4.693(1.349–18.558), p = 0.020), and male (AOR =3.77 (1.34–10.57), p = 0.012), were significantly associated with outcomes of acute poisoning. Conclusion: Acute poisoning at WCSH predominantly affects young females from rural. Intentional ingestion of pesticides was commonly involved. While most patients recover, mortality remains concerning in male patients and those patients who were arrived after 1hour of exposure. These findings highlight the need for targeted public health strategies to enhance early access to emergency care is key in reducing incidence and severity of poisoningenPoisonTreatmentOutcome.Thesis