Melkie, Addisu(MD, Internist and Consultant in Nephrology)Seifu, Lissane(MD, Internist and Consultant in Nephrology )Abdi, Semir2021-02-112023-11-052021-02-112023-11-052021-02http://etd.aau.edu.et/handle/123456789/25062Background: Anemia is common and significant complication of chronic kidney disease (CKD). Anemia of chronic kidney disease is associated with significant cardiovascular morbidity mortality and poor quality of life. However, its prevalence and management has not been studied thoroughly at local and national level. Objective: To assess the prevalance, severity and management of anemia among predialysis chronic kidney disease (CKD) patients on follow up at Tikur Anbessa Specialized hospital (TASH) renal clinic. Methods and Materials: A hospital based cross sectional hospital study was conducted from April 1 to July 30, 2020. Consecutive sampling was used to recruit 100 study participants. participants were interviewed using structured questionnaire, and their medical records were reviewed to obtain information on relevant medical history and laboratory parameters. Serum Iron panel was determined for all enrolled patients. Data was analyzed using SPSS version 26. Continuous variables were presented as means ± standard deviations and compared by t-test. Categorical variables were expressed as count with percentage and compared by Chi-square. Bivariate and multivariate logistic regression analyses were used to identify independently associated factors of anemia. P-value <0.05 was used to declare association. Results: the burden of anemia in CKD was high (48%) and its prevalence increased with worsening kidney function. Diabetes (40%) and hypertension (25%) were the leading causes of CKD. CKD stage, iron marker and BMI were found to be independent determinant of anemia among CKD patients. Among patients with anemia, only 35.4% were treated, only 27% of patients were managed with iron agent and only 8.3% were managed with ESA. Conclusion: Screening and intervention programs should be implemented to improve the outcome of CKD patients with anemia. Grant source: Addis Ababa University, college of health sciences, school of medicineen-USChronic kidney disease, anemia, Ethiopia.Thesis