Assessment of multi drug resistant tuberculosis rate and associated factors in public health facilities of Dessie City Administration, North East Amhara, Ethiopia

Abstract

Assessment of multi drug resistant tuberculosis rate and associated factors in public health facilities of Dessie City Administration, North East Amhara, Ethiopia. Gashaw Shegaw Addis Ababa University, 2015 The history of TB treatment has observed sequential development of resistance to anti-TB drugs. MDR-TB is defined as an MDR-TB suspect who is sputum culture positive and whose TB is due to Mycobacterium TB that are resistant in-vitro to at least INH and RMP. The emergence of MDR-TB is a threat for the populations of resource limited countries. In Ethiopia MDR-TB is becoming a challenge, because of poor adherence to treatment, TB/HIV co-infection, a few diagnostic and treatment facilities and inadequate trained health professionals. Dessie is densely populated town with high flow of people within the region as well as from neighborhood regions. It is also vulnerable for counterfeit anti-TB drugs through contraband. The aim of this study is to determine rate of MDR-TB and to identify associated factors in Dessie City Administration, North East Amhara, Ethiopia. A facility based retrospective cross sectional study design employing medical records review of TB registration books supplemented by key informants’ interviews which cover retrospective review period of July 1, 2012 to June 30, 2014. Prevalence rate of MDR-TB for combined, new and retreated TB cases of all form from public health facilities, were found to be 2.1/100, 0.3/100 and 21.6/100 respectively. Adherence of TB patients to TB treatment (COR=9.0, 95% CI [1.03-78.57]) and previous history of TB treatment (AOR=66.87, 95% CI [6.94-644.10]) were found to be a risk factors for MDR-TB. And related to TB type all MDR-TB cases were dominantly pulmonary TB.