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Innate Immunity to Tuberculosis in advanced HIV/AIDS patients

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dc.contributor.advisor Howe, Rawleigh (PhD)
dc.contributor.advisor Abebe, Markos (PhD)
dc.contributor.author Tariku, Tewodros
dc.date.accessioned 2018-07-12T08:56:22Z
dc.date.available 2018-07-12T08:56:22Z
dc.date.issued 2012-07
dc.identifier.uri http://localhost:80/xmlui/handle/123456789/8323
dc.description.abstract Several factors influence resistance or susceptibility to tuberculosis (TB) in an immunocompromised host. Animal studies have shown the contributions innate immunity on host resistance to TB disease in the absence of intact adaptive immunity (Feng et al., 2006). We extended these observations to humans to assess the innate mechanisms that prevent the development of active TB in advanced AIDS patients with compromised CD4+ T cell functions. In a cross-sectional study, we determined macrophage mediated killing of Mycobacterium tuberculosis (M. tuberculosis ) and measured the production of inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-α) and interleukin-10 (IL-10). We also assessed intracellular expression of IFN-γ in NK, γ/δ (CD3+ γ/δ+) and adaptive (CD3+ γ/δ -) cells in response to purified protein derivative (PPD) and live M. tuberculosis . We found better innate functions in macrophage killing and IFN-γ production in AIDS patients with latent TB infection compared to AIDS patients who progress to TB disease, but the differences did not reach statistical significance. The study suggests that variation in susceptibility to TB in AIDS patients could be due to innate immunity but our observation warrants confirmation in larger prospective study to consolidate this hypothesis. A better understanding of these factors might help in making preventive therapies to HIV patients that are most likely to develop TB. Keywords: Innate immunity, Susceptibility, Resistance, Latent TB infection en_US
dc.language.iso en en_US
dc.publisher Addis Ababa University en_US
dc.subject Innate immunity en_US
dc.subject Susceptibility en_US
dc.subject Resistance en_US
dc.subject Latent TB infection en_US
dc.title Innate Immunity to Tuberculosis in advanced HIV/AIDS patients en_US
dc.type Thesis en_US

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