The use of locally available, nutrient rich organic sources is an effective means for improving soil fertility and increasing crop yield in view of the escalating cost of inorganic fertilizers and low fertilizer use efficiency of crops in Ethiopia. This study was conducted in Sebeta Hawas Woreda with the objective of comparing the effectiveness of bio-slurry and inorganic fertilizer on soil properties, growth and yield of white cabbage. The questionnaire survey was done to obtain information on the family size, number of cattle, type of fertilizer used, the amount of money saved by biogas using households when replacing chemical fertilizer with bio-slurry, bio-slurry storage and management, household yield increment and perception of soil fertility improvement by using bioslurry as organic fertilizer. Laboratory analysis and field experiment were done on bioslurry in liquid and composted form to determine the nutrient content and effect of bioslurry and inorganic fertilizer on plant height, number of leaves, head diameter, head yield and nutrient content of cabbage as well as physical and chemical properties of the soil. The maximum plant height (cm) was obtained from T6 (recommended dose of inorganic fertilizer (RDIF) + biogas slurry compost (BGSC) at (80q/ha), while the lowest plant height (cm) was recorded in T1 (control). Cabbage plants treated with T7 ( (1/2 RDIF) + iv (½ BGSC )), T6 ( (RDIF) + BGSC at 80q/ha),T5 (BGSC at (80q/ha)) and T6 showed the highest number of leaves at 2,4,6 and 8 weeks after transplanting respectively. With regard to fresh weight of individual head and individual head diameter (cm), T6 showed the highest value for fresh weight of individual head and T5 showed the highest values for individual head diameter (cm). Considering major nutrient content of white cabbage, it can be inferred that bio-slurry and inorganic fertilizer showed no significant effects on leaf phosphorous and potassium value but bio-slurry applied in combination with inorganic fertilizers has positive influence on nitrogen content. The study also revealed that there was significant contribution of bio-slurry to increase organic carbon, phosphorus and cation exchange capacity of soil. Key words: Growth and head yield, soil properties, bio-slurry, fertilizer