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Bacterial Meningitis: A Five Year Retrospective Study Among Patients Who Had Attended at University of Gondar Teaching Hospital

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dc.contributor.advisor Gebreselassie, Solomon (PhD)
dc.contributor.author Tegene, Birehanemeskel
dc.date.accessioned 2018-07-04T12:41:19Z
dc.date.available 2018-07-04T12:41:19Z
dc.date.issued 2011-03
dc.identifier.uri http://localhost:80/xmlui/handle/123456789/6453
dc.description.abstract Background: Bacterial meningitis is one of the most serious infectious diseases. The most frequent causes of meningitis are Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae. The infection usually associated with a high rate of complications. Data on the recent relative magnitude of the bacterial isolation and their antibiotic susceptibility patterns is insufficient in Ethiopia. Objectives: The aim of the study was to determine etiological agents of bacterial meningitis at University of Gondar Teaching Hospital and assess their antibiotic susceptible pattern during last 5 years Methods: This is a retrospective analysis of three thousand and eighty five cerebrospinal fluid specimens submitted to the bacteriology laboratory of Gondar University Hospital for culture and antibiotic susceptibility patterns in a period between January 2006 and December 2010. The study was done from November 1, to December 31, 2010. Results: For this retrospective study data were obtain from 1589 males and 1496 females making male to female ratio 1.06:1 of suspected cases of meningitis in Gondar University Hospital. The etiological agent had been identified in 120 (3.8%) of the total 3085 CSF samples by culture. Thirty- nine (32.5%) of them were infants below the age of 12 months. Streptococcus pneumoniae was the predominant pathogen accounting for 52 (43.3%) of the cases. Whereas Neisseria meningitidis and Haemophilus influenzae accounted for 27(22.5%), and 12(10%) respectively. Other gram negative bacilli and Staphylococcus aureus were isolated from 21(17.2%), and 11(9.2%) cases respectively. Among gram positive organisms S.pneumoniae showed a high level of drug resistance against co- trimoxazole 44(84.3%), tetracycline 17(32.6%), gentamicin 10(19.2%) chloraphinicol 4(7.6%) and ampicillin 3(5.7%). Among gram negative bacteria, N.meningitidis was found to be resistant to Co- trimoxazole in 25(92.5%), Chloraphinicol 2(7.5%), Gentamicin 4(14.8%) and Ampicillin 4(14.8%). E. coli and salmonella spp. were found to be resistant to most antibiotics except ciprofloxacin. Both S. Pneumoniae (7.6%) and S. aureus (18.1%) were found to be resistant to ciprofloxacin. Multiple drug resistance was observed in 58.3% of the isolates. Conclusions and recommendation: Streptococcus pneumoniae remains the major aetiological agent of Community Acquired Acute Bacterial Meningitis (CAABM) both in adults and children in the study area. 5.7% of Streptococcus pneumoniae were resistances to penicillin. Further research should focus on preventable aspects CAABM of, especially pneumococcal vaccines, to reduce the disease burden. Keywords: bacterial meningitis, antimicrobial susceptibility and pyogenic meningitis. en_US
dc.language.iso en en_US
dc.publisher Addis Ababa University en_US
dc.subject Bacterial meningitis en_US
dc.subject Antimicrobial susceptibility and pyogenic meningitis en_US
dc.title Bacterial Meningitis: A Five Year Retrospective Study Among Patients Who Had Attended at University of Gondar Teaching Hospital en_US
dc.type Thesis en_US


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