The main purpose of this study was to asses the abuse of drug among secondary school students and to examine the prevalence rate of drug abuse among secondary school students. Basic questions were raised regarding the spread of drug abuse, its relationship with some variables of the study population such as family condition, peer influence, and level of academic performance and on drug abuse manner and its consequences. The study was carried out in Harari region. To select 3 sampled secondary schools from the 7 secondary schools found in the region, simple random sampling method was used and to include the sampled grades, stratified sampling method was employed. Furthermore, students’ section was used as a stratum to select sample from sampled grade, then simple random sampling method was used to select subjects from the sampled section. Students who participated in filling the questionnaire were also included in the focus group discussion by selecting them randomly and the key informants were included in the study purposefully because they would provide relevant information by virtue of their position. The sample schools included were 325 students. To deal with the objectives and basic questions, mixed method design was employed. The instruments used to gather the required information for the study were questionnaire, focus group discussion guide and interview. The obtained data were analysed through frequency, percentage and chi square. Based on the analysis, the following major findings were obtained: Alcoholic drinks, khat, shisha and cigarette were the main commonly consumed drugs by secondary school students. Risk factors for drug abuse is significantly associated with lifetime Drug abuse at P<.05, df=12 and level of academic performance at X2 (9, N=213) =53.779, P<.05 Whereas, sex is not significantly associated with lifetime Drug abuse at X2 (3, N=213)=5.533,P>.05.Behavioural, psychological, health and social consequences were the problems faced by the students due to their drug abuse behaviour which results trouble on their education directly or indirectly. parents, teachers and peers should react positively, efforts should be made to design and implement drug abuse assessment programs, Laws should be amended in the school to control the drug trafficking and to create a drug free environment, awareness should be raised about the nature and consequences of drug abuse through the region’s media and school media, recreational amenities and youth centers like public libraries by concerned body should be given due attention, individual, peer and group counselling sessions on drug abuse, should be designed, campaigns should be prepared on drug abuse and further research should be conducted and disseminated to concerned bodies