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Evaluation of the Anti Peptic Ulcer Activity of the Leaf Extract of Plantago Lanceolata in Rodents.

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dc.contributor.advisor Engidawork, Ephrem
dc.contributor.author Melese, Endale
dc.date.accessioned 2022-05-11T09:56:10Z
dc.date.available 2022-05-11T09:56:10Z
dc.date.issued 2010-02
dc.identifier.uri http://etd.aau.edu.et/handle/123456789/31616
dc.description.abstract The lesion of peptic ulcer disease (PUD) is a disrflption in the mucosal layer of the stomach or duodenum. An ulcer is di stinguished from erosion by its penetration through the muscularis mucosa or the muscular coating of the gastric or duodenal wall. PUD results from the imbalance between defensive factors that protect the mucosa and offensive factors that disrupt this important barrier. There are several different types of modern drugs for the treatment of PUD though they are associated with clinically significant drug interactions, side effects, and relapse. Thus, there is a need to develop new drugs. for which natural products are potential candidates. Planlago lanceolala is used traditionally for the treatment of upper respiratory inflammation, urinary conditions. uterotonic. vascular disorders. wound, cough, ulcer etc. The present study was undertaken to evaluate the anti ulcer activity of the aqueous extract, and mucilage of P. lanceolala using different rodent models of PUD. Negative controls were given distilled water. Whilst positive controls received ranitidine in acetic acid induced chronic gastric ulcer, cysteamine Hel induced duodenal ulcer and pylorus ligation induced gastric ulcer models; misoprostol was used in indomethacin induced gastric ulcer. One group of animals received 200 mg/kg (for mice) and the other group received 400 mg/kg (for mice) of the aqueous extract in each model. In addition, one group of animals received 172 mg/kg of the mucilage in acetic acid induced chronic gastric ulcer model. The aqueous extract showed a better healing of ulcer than the mucilage in the acetic acid induced chronic gastric ulcer as evidenced by the higher percent reduction in ulcer index (77.9% vs 51.9%) and ulcer score Crable I). The aqueous extract was therefore, used for further evaluation. The effect of the aqueous extract at 400 mg/kg was more effective in healing and/ or protecting ulcer in virtually all models than 200 mg/kg. The extract at both 200 mg/kg and 400 mg/kg produced reduction in ulcer index (P<0.05 and P<O.OO I respectively) as compared to the negative control in acetic acid induced chronic gastric ulcer. However. it was only 400 mg/kg of the extract that produce a significant reduction (P<O.OI) in the ulcer score as compared to the negative control. In addition, the percent reduction in the ulcer index by 400 mg/kg of the extract was higher than ranitidine (77.9 % vs 76.2%). Similar results were also found on the ulcer score in pylorus ligation induced gastric ulcer. The aqueo us extract at 400 mg/kg was found to offer significant protection In indomethac in induced stomach Illcer as compared to the negati\'e cpntrol ' . (P<O.OO I) as \\ ell as to the 200 lllg/kg or the extract (P<O.O I). Moreover, it appeared to reduce the ulcer score by 86.4% while misoprostole reduced it by only 68.2%, Ranitidine protected the ulcerogenic effect of cysteamine HCI by 73.3% while 400 mg!kg offered protection by 60% indicating ran itidine is more effec tive in inhibition of acid secretion than the extract. In conclusion, the aqueous extract at 400 mg/kg showed a better activity against gastric as well as duodenal ulcer than the standard drugs. Moreover. some of the possible mechanisms by which the extract showed the activity were corroborated to be anti secretory and cytoprotection. Thus, the present work up holds the traditional use of the plant for PUD, Keywords: Peptic ulcer disease, Acetic acid induced chronic gastric ulcer, Pylorus ligation induced gastric ulcer. Cysteamine HCI induced duodenal ulcer, Indomethacine induced gastric ulcer, and P. /an ceo/ala. en_US
dc.language.iso en en_US
dc.publisher Addis Ababa University en_US
dc.subject Evaluation of the Anti Peptic Ulcer Activity en_US
dc.title Evaluation of the Anti Peptic Ulcer Activity of the Leaf Extract of Plantago Lanceolata in Rodents. en_US
dc.type Thesis en_US

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