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Evaluation of Hematological and Lipid Profiles in Pulmonary Tuberculosis Patients: A case control Study at Metema and Gondar Referral Hospitals, North West Ethiopia

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dc.contributor.advisor Tsegaye, Aster (PhD)
dc.contributor.author Yesuf, Mohammed
dc.date.accessioned 2018-06-22T07:44:42Z
dc.date.available 2018-06-22T07:44:42Z
dc.date.issued 2017-08
dc.identifier.uri http://localhost:80/xmlui/handle/123456789/2884
dc.description.abstract Background: Tuberculosis is one of the first most common causes of deaths in the world alongside HIV/AIDS, causing more than 9.6 million new cases and 1.5 million deaths globally in 2014 alone. This infection also accompanied by hematological and lipid profile alterations. The hematological and lipid alteration related to the disease is not yet well determined and has variation in different studies. Objective: This study aimed at evaluating hematological and lipid profiles in pulmonary tuberculosis patients in Metema hospital and Gondar referral Hospital, North West Ethiopia. Materials and methods: A case control study design was implemented from January to July 2017. One to one case to control ratio was used and a total of 88 blood samples were collected. There were 44 samples from tuberculosis patients and 44 samples from apparently healthy individuals. Collected bloods were tested using Hematology analyzer (sysmex) and Mindray chemistry analyzer for hematological and lipid profiles, respectively. Results: The mean + SD of hemoglobin, hematocrit and red blood cell count of the pulmonary tuberculosis patients were significantly lower than control groups (P < 0.05). However, platelet counts, total white blood cell counts, and erythrocyte sedimentation rate were significantly increased as compared with control groups (p<0.05).The mean serum levels of triglyceride, total cholesterol, high density lipoprotein and low density lipoprotein were significantly lower than their respective control groups (p=0.001). Body mass index had significant positive associations with RBC counts, HGB, and HCT and serum levels of TC and LDL (P < 0.05). Conclusion: Pulmonary Tuberculosis patients in this study had hematological and lipid profile abnormalities. RBC count, HCT and HGB were significantly reduced. However, TWBC count, thrombocyte, and ESR of TB patients were significantly elevated than control group. Total Cholesterol, HDL, LDL and TG concentrations were significantly reduced as compared with control groups. The factors associated with hematological and Lipid profiles also due attention to prevent further complication. Keywords: Case, Control, Lipid profile, Hematological profile, Tuberculosis. en_US
dc.language.iso en en_US
dc.publisher Addis Ababa University en_US
dc.subject Case; Control; Lipid profile; Hematological profile; Tuberculosis. en_US
dc.title Evaluation of Hematological and Lipid Profiles in Pulmonary Tuberculosis Patients: A case control Study at Metema and Gondar Referral Hospitals, North West Ethiopia en_US
dc.type Thesis en_US


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