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Evaluation of anticonvulsant activity of aqueous and 80% methanol extract of Pterolobium stellatum (Forssk)in Swiss albino mice

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dc.contributor.advisor Dr.Nedi, Teshome
dc.contributor.author Hussien, Yimer
dc.date.accessioned 2021-01-13T08:31:19Z
dc.date.available 2021-01-13T08:31:19Z
dc.date.issued 2020-06
dc.identifier.uri http://etd.aau.edu.et/handle/123456789/24641
dc.description.abstract Pterolobium stellatum is used for the treatment of various illnesses including tuberculosis, pneumonia,and epilepsy in Ethiopian traditional medicine. The present study was conducted to evaluate anticonvulsant activity of aqueous and 80% methanol extract of Pterolobium stellatum (Forssk)in Swiss albino mice using pentylenetetrazole (PTZ) induced seizure test. In addition, anticonvulsant activity of the study plant was evaluated using maximal electric shock (MES)induced seizure tests. The effect of both aqueous and 80% methanol extract on motor coordination was evaluated using a rota rod test. The 80% methanol extract has shown a dose dependent increase in latency to onset of seizure against PTZ induced seizure tests. In addition, both aqueous and 80% methanol extract have shown dose-dependent reduction in duration of hind limb tonic extension against MES induced seizure test. Furthermore, the aqueous extract at dose 400mg/kg and methanol extract at doses 200mg/kg and 400mg/kg possess a significant reduction in duration of myoclonic seizure in the PTZ test (P<0.05, P<0.05and P<0.01)respectively. Similarly,administration of 80 % methanol extract at all tested dose levels (100mg/kg, 200mg/kg and 400mg/kg) and aqueous extractat the dose level of 200mg/kg and 400 mg/kg have shown significant reduction on the duration of hind limb tonic extension (HLTE) in MES induced convulsion tests. All animals received both aqueous and 80% methanol extract at the dose level of 100mg/kg, 200mg/kg and 400mg/kg did not show motor deficit inrota road test. Phytochemical screening tests on both aqueous and 80% methanol extract revealed the presence of alkaloids,tannins, saponins,terpenoids, and steroids. The present study revealed that the aqueous and 80% methanol leaf extracts of Pterolobium stellatum possess anticonvulsant activity in PTZ and MES induced seizure tests. Results of the present study validated the traditional use of the study plant in the treatment of epilepsy, as its hydroalcoholic extract pretreatment prevents MES and PTZ-induced convulsions in mice. en_US
dc.language.iso en_US en_US
dc.publisher Addis Abeba University en_US
dc.subject Seizurepentylenetetrazole maximal electric shock rota rod Laboratory animals Pterolobium stellatum en_US
dc.title Evaluation of anticonvulsant activity of aqueous and 80% methanol extract of Pterolobium stellatum (Forssk)in Swiss albino mice en_US
dc.type Thesis en_US


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