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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/17279
Title: Incidence of severe acute side effects of radiotherapy or concurrent chemo-radiation therapy in patients with locally advanced cancer of uterine cervix treated at the radiotherapy department of Tikur Anbessa Specialized Hospital: A Prospective Study
???metadata.dc.contributor.*???: Wondimagegnehu Tigeneh (MD,FCRad,Onc(SA)
Eva Kantelhardt (MD, OBG\GYN )
Ahmedin Jemal (DVM,PHD)
Edom Seife
Keywords: Cancer of the uterine cervix
Issue Date: Jul-2017
Publisher: AAU 2017
Abstract: Introduction: Cancer of the uterine cervix is the second most commonly diagnosed cancer and a leading cause of cancer death in Ethiopia. A substantial proportion of these cases are diagnosed at a locally advanced stage for which concurrent chemo-radiation therapy (CCRT) is the standard of care. Several previous studies reported on the acute side effects of CCRT and radiotherapy (RT) for locally advanced cervical cancer but few of these studies were from Africa and none from Ethiopia. Objective: to determine the incidence of severe acute side effects of RT or CCRT among patients with locally advanced uterine cervix cancer treated at the radiotherapy department of Tikur Anbessa Specialized Hospital. Methodology: An institution based prospective follow-up study of 57 locally advanced uterine cervix cancer patients treated with cobalt 60 RT alone (83%) or CCRT (17%) was conducted. Acute toxicity of the gastrointestinal (GI), genitourinary (GU) system and skin was assessed using radiation therapy oncology group (RTOG) acute radiation toxicity assessment format weekly during treatment and one month after the end of treatment. Result: About 12% of the patients had severe acute toxicity of RT or CCRT. The most common severe acute toxicity occurred in the lower GI (7%) followed by the skin (5%). Among the 10 patients who received CCRT two had severe acute toxicity while five out of the 47 who were treated with RT alone experienced severe acute toxicity. Conclusion and recommendation: A little more than one sixth of locally advanced stage cervical cancer patients treated with RT or CCRT in Tikur Anbessa Specialized Hospital had severe acute side effects of these treatments. Due attention with weekly follow-up should be instituted. Future studies should examine acute and late side effects of these treatments separately in a large cohort of patients.
Description: A thesis submitted to the Department of Clinical Oncology, School of Medicine, Addis Ababa University presented in partial fulfillment of the requirements for the certificate of specialization in clinical oncology
URI: http://hdl.handle.net/123456789/17279
Appears in Collections:Thesis - Toxicology

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