|Title:||Body mass index, blood pressure, hematological profiles and non-enzymatic antioxidants status in type 2 diabetic patients: a cross sectional study.|
|???metadata.dc.contributor.*???:||Gnana S, PhD Department of Biochemistry, School of Medicine Addis Ababa University, Addis Ababa, Ethiopia|
Daneal Seifu , PhD Department of Biochemistry, School of Medicine Addis Ababa University Addis Ababa, Ethiopia.
Mennon M.K.C, PhD Department of Biochemistry, School of Medicine Addis Ababa University Addis Ababa, Ethiopia
|Keywords:||Diabetes, oxidative stress, hematological abnormalities, vascular complications|
|Abstract:||Background: Type 2 Diabetes Mellitus (T2DM) is commonly associated with vascular complications. In recent years, there has been renewed interest and increasing evidences that hematological abnormalities can be used as indicators of endothelial dysfunction and inflammation and thus, are responsible for both micro- and macro-vascular complications. Objective: The aim of the present study was to investigate the average values of Body mass index, Blood Pressure, hematological profiles and non-enzymatic antioxidants status in Type 2 Diabetic Patients. Methods: This study involved 70 patients with T2DM (male/females, 47/23) and 70 age and sex matched non diabetic healthy individuals (male/females, 46/24). The study was conducted from December 2016 to January 2017, which was a cross-sectional study. Anticoagulated Blood samples were collected from fasting individuals and analyzed in automated blood cell counter. Serum fasting blood sugar (FBS), uric acid (UA), and Total Bilirubin (TB) were analyzed using automated chemistry analyzer. The results were statistically analyzed by SPSS, V21 software. Two tailed significance level was determined by independent t-test. P values less than 0.05 (P<0.05) were considered as statistically significant and results presented as mean ± standard deviation. Result: Male diabetics were characterized by significantly elevated levels of; body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean cell hemoglobin (MCH), red blood cell distribution width (RDW), platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), FBS (P<0.05) and lower values of UA (P<0.05) as compared with the normal controls. Even though statistically not significant, mean values of hematocrit (HCT), mean cell hemoglobin concentration (MCHC), white blood cell count (WBC) and platelet crit (PCT) (P>0.05) were higher while mean values of red blood cell (RBC and TB (P>0.05) were lower in male patients. Similarly, female diabetics were characterized by significantly elevated levels of DBP, HCT, MCHC, RDW, WBC, PLT, MPV, PCT, and FBS (P<0.05). However, they had significantly lower values of DB and UA (P<0.05) than their corresponding female controls. Higher values of BMI, SBP, PDW and lower values of RBC were also observed in female patients but these differences were not statistically significant. CONCLUSION: This study revealed remarkably elevated levels of anthropometric parameters such as BMI, SBP, DBP in male and DBP in female diabetics as compared with their corresponding healthy individuals. Hematological parameters like; RDW, PLT and MPV were considerably higher in both sexes of diabetic patients compared with their corresponding healthy individuals. MCH and PDW showed a significant elevation in male patients while HCT, MCHC, WBC and PCT were justifiably higher in female patients. This study also demonstrated significantly lower values of Non-enzymatic antioxidants like UA and TB in female and TB in male diabetic patients as compared with the healthy individuals.|
|Description:||A Thesis Submitted to the School of Graduate Studies of Addis Ababa University in Partial Fulfillment of the Requirements for the Degree of Masters of Science (M.Sc) in Medical Biochemistry|
|Appears in Collections:||Thesis - Medical Biochemistry|
|CHALA OLANA.pdf||MEDICAL BIOCHEMISTRY||1.5 MB||Adobe PDF||View/Open|
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