The purpose of this study was to assess the factors that affect teachers’ job satisfaction in secondary schools of Gurage Zone in Southern Nations and Nationality and Peoples’ Regional State (SNNPR). As teachers work harder, adequately compensated they will likely perform better and they will be satisfied in their jobs. Understanding the factors that affect teachers’ job satisfaction could help the educators to reduce causes of teachers’ dissatisfaction with their job. Also the study tried to examine the difference between male and female teachers’ in their level of job satisfaction in the Zone. Moreover, the study attempted to identify the relationship between job satisfaction of teachers and their years of service in the study area. To this end, a descriptive survey design was employed. The sources of data for this study were secondary school teachers, principals and woreda Education office heads. Among 11 woredas in the Zone, 3 woredas were selected using simple random sampling techniques. Also among 26 secondary schools of the Zone, 6 schools were selected by using simple random sampling techniques. Two schools from each woredas were included in the study. As mentioned above, 175 teachers’ were selected by using simple random sampling system. In addition to, 12 principals and 3 woreda Education office heads were selected by using purposive sampling technique. Instruments used to collect data were questionnaires, semi-structured interview and focus group discussion. To describe the quantitative data statistical tools like SPSS version, mean, frequency count, percentages and standard deviation were used. Based on the analyses the result of the study revealed that teachers were discouraged and dissatisfied due to students misbehaviors and often do not attend their lesson regularly. Most of the teachers agreed that there were inadequate materials (resources or facilities) in their schools to carry out the teaching learning process in their respective schools. Hence, the management does not participate staffs in the decision making or recommend possible solution for the ultimate decision making thereof. The study also indicated that the salary they received was not enough (adequate) to support their family. Furthermore, the study revealed that in most schools the system of administration was not as such democratic and participatory in their respective schools. Based on the major findings of the study, it was concluded that most of the teachers were not satisfied with their job in the study area. Finally, it is recommended that school principals, Woreda Education offices, Zone Education Department and the community at large work together to improve the level of satisfaction of teachers in the Zone.