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Title: Studies on the Survival, Fecundity and Fertility of Anopheles Arabiensis by Feeding on Longrange™ Eprinomectin Treated Cattle
???metadata.dc.contributor.*???: Prof. Beyene Petros
Belay, Kehulu
Keywords: Anopheles Arabiensis;Cattle;Longrange Eprinomectin;Malaria Control;Ethiopia
Issue Date: Apr-2017
Publisher: Addis Ababa University
Abstract: Malaria is a serious public health and economic problem in Ethiopia for about 68% of the population. The misuse of LLINs and resistance of the vectors to most of the insecticides used in LLINs and IRS necessitated the need for alternative and effective control methods. Reports showed that Anopheles mosquitoes die when they feed on endectocidal drug- (like ivermectin and eprinomectin) treated humans and animals. This study was designed to investigate the efficacy of LongRange™ eprinomectin against laboratory reared Anopheles arabiensis when fed on treated calves. Three local breed calves treated with a therapeutic dose of LongRange™ Eprinomectin (1ml / 50Kg body weight) and another three non-treated calves (control) were exposed to equal numbers of An. arabiensis mosquitoes. The mosquitoes were placed in paper cups, covered with meshed nylon cloth and then allowed to feed on calves’ neck. Subsequently, their survival, fecundity, egg hatchability, larval development and adult emergence were recorded. Data were entered and analyzed by using the SPSS version 20. Kaplan-Meier survival analysis and, independent samples t-test were used. The survivorship of An. arabiensis that fed on LongRange™ Eprinomectin treated calves up to14 days post treatment was observed to be reduced significantly (p< 0.001). All of the mosquitoes that fed on the treated calves within 7 days following injection were observed to die. Although not statistically significant, fecundity and hatchability of An. arabiensis that fed on the treated calves were reduced. Hence, treatment of livestock with eprinomectin can be used to effectively control zoophagic An. arabiensis for 7days post- injection. Therefore, the drug can be used as part of a combination vector control tool against An. arabiensis effectively if a repeated MDA is given to cattle in malarious regions of Ethiopia.
Description: Msc Thesis Submitted to Department of Microbial, Cellular and Molecular Biology, College of Natural Sciences, Addis Ababa University
Appears in Collections:Thesis- Microbial, Cellular and Molecular Biology

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