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Title: The Application of the Enzyme Linked Immunosorbent Assay (ELISA) in the Serodiagnosis of Schistosomiasis
???metadata.dc.contributor.*???: Dr. M. D. Melamed
Taticheff, Seyoum
Issue Date: Jun-1980
Publisher: Addis Ababa University
Abstract: A description of the schistosome parasite and its life cycle, its immunology and the fact that the parasite causes a disease of world-wide significance is made. The existing distribution of schistosomiasis in Ethiopia and its recorded vectors and the possibility that the disease may rapidly be coming a public health threat is mentioned # As possible tools for the sero-diagnosis of schistosomiasis, short accounts of the skin test, the indirect immuno-fluorescence test, the complement fixation test and the radio-immunoassay are given. The enzyme linked immunosorbent assay (ELISA) as a piaomising diagnostic method has been elaborated. The primary objective of this study was the assessement of ELISA as a sero-epidemiologic tool for schistosomiasis. In this study, samples from S. mansoni and - S.haematobium endemic areas and samples from non-endemic area were used. Microscopic examination of stool and/or urine ELISA on blood samples and skin tests for schistosomiasis were done. ELISA with a sensitivity of 86.86 to 96% and a specificity or 80 to 81% was preferred as a sero-diagnostic method for schistosomiasis from: the conventional microscopy where sensitivity was low and from the intradermal test which showed poor specificity (4C% positivity was observed in, non-endemic area).
Description: A Thesis Presented to The School of Graduate Studies Addis Ababa University In Partial Fulfillment of the Requirements for the Degree Master of Science in Biology.
Appears in Collections:Thesis - Biology

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