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???metadata.dc.contributor.*???: Dr Diresibachew Haile (PhD)
Yosef Eshetie
Keywords: Pregnancy, high altitude, dynamic lung volumes.
Issue Date: Feb-2017
Publisher: AAU
Abstract: ABSTRACT Introduction: Pregnancy is characterized by sequence of dynamic physiological changes that impact on multiple organ system functions. The increasing size of the fetus with advancing gestation and associated hormonal changes constitute a mechanical impediment to normal process of maternal ventilation. As the uterus expands, the diaphragm is pushed up as much as 4 centimeter. Precise knowledge of the pulmonary function test parameters helps to understand and manage the course and outcome of pregnancy leading to safe delivery. It also helps to avoid misdiagnosis and unnecessary interventions. Objective: The aim of this study was to determine the effect of normal pregnancy on pulmonary function tests among women that visit Antenatal care clinic in Debere Berhan Referral Hospital, Ethiopia. Methods: Comparative cross-sectional study design was used in Debere Berhan referral Hospital. A total of 176 study participants were enrolled by convenience sampling technique and categorized in to four groups (those in their first, second and third trimesters, and control). Each group comprised of 44 study participants. Written consent was obtained; anthropometric data, saturation of arterial blood and pulmonary function testes were collected using height and weight measuring scales, pulse oximetery (Oxi-Max N-65), and spiropro® (Courtesy of Jaeger/Cardinal Health, Hochberg, Germany) respectively. Data was tabulated and analyzed using SPSS version 20.0 statistical software. Results: Mean of FVC for the controls, first, second, and third trimesters were (2.59 ± 0.26, 2.13 ± 0.15, 1.93 ± 0.27, and 1.90 ± 0.11 liters) respectively. Except similar FEV1%, the mean value of FVC, FEV1, PEFR, and FEF 25-75% in pregnant group (at all three trimesters) were significantly decreased from the controls (P<0.05). Strong negative correlation was seen between SaO2 and RR (r= -0.865; P <0.01). Conclusion: As pregnancy progressed from first to third trimester, dynamic pulmonary function tests (FVC, FEV1, FEF25-75% and PEFR) were dropped and respiratory rate increased. Thus, the results had shown tendency of obstructive pattern while pregnancy becoming advanced. Remarkable decline in SaO2 was observed in pregnant women that might be counterbalanced by raised respiratory rate.
Description: A Thesis Submitted to the School of Graduate Studies of Addis Ababa University in Partial Fulfillment of the Requirements for Master of Science Degree in Medical Physiology
Appears in Collections:Thesis - Medical Physiology

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