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Title: Evaluation of Lipid Profiles and Hematological Parameters in Hypertensive Patients: A Cross Sectional Study at Debre Markos Referral Hospital, North West Ethiopia
???metadata.dc.contributor.*???: Dr. Natesan Gnanasekaren
Dr. Menakath Menon
Alemu Gebrie
Keywords: Hypertension, Lipid profiles, Hematological parameters, Anthropometric indicators
Issue Date: Mar-2017
Publisher: AAU
Abstract: ABSTRACT Introduction: Hypertension and dyslipidemia are the two coexisting and synergizing major risk factors for cardiovascular diseases. The cellular constituents of blood affect the volume and viscosity of blood, thus playing a key role in regulating blood pressure. Overweight and obesity are key determinants of adverse metabolic changes including increase in blood pressure. Objective: The aim of the present study was to evaluate lipid profiles and hematological parameters in hypertensive patients at Debre Markos Referral Hospital, North West Ethiopia. Materials and methods: Hospital based cross-sectional study was conducted in 100 hypertensive patients at Debre Markos Referral Hospital. The required amount of blood was withdrawn from the patients by health care professionals in the hospital for the immediate automated laboratory analysis of the blood sample. Data were collected on sociodemographic factors, anthropometric measurements, blood pressure, lipid profiles and hematological parameters. Result: The mean serum levels of Triglyceride (TG), Total Cholesterol (TC) and Low Density Lipoprotein (LDL) were significantly higher than their respective cut-off values in the hypertensive patients. 54%, 52%, 35%, 11% of the hypertensive patients had abnormal LDL, TC, TG and High Density Lipoprotein (HDL) levels respectively. Higher levels (p<0.05) of LDL, hemoglobin and Red Blood Cell (RBC) count were observed in the hypertensive patients whose blood pressure had been poorly controlled than the controlled ones. Waist circumference had significant positive association with the serum levels of TC and White Blood Cell (WBC) count (p<0.05). Conclusion: The hypertensive patients in this study had high prevalence of lipid profile abnormalities and poorly controlled blood pressure which synergize in accelerating other cardiovascular diseases. Some hematological parameters like RBC count are also increased as do the severity of hypertension.
Description: A Master’s thesis submitted to the department of medical Biochemistry, school of Graduate Studies, Addis Ababa University in partial fulfillment of the requirements for the degree “Master of Science in Biochemistry” in the department of medical Biochemistry
Appears in Collections:Thesis - Medical Biochemistry

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