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Title: Chemical Composition of Croton Macrostachys Root-·Bark
???metadata.dc.contributor.*???: Dr. Berhanu Abegaz
Menberu, Dirshaye
Issue Date: Jun-1981
Publisher: Addis Ababa University
Abstract: The root--bark powder of Croton macrostachys Hochstex. A. Rich. (Euphorbeaceae) (ብስና ), used in Ethiopia for curing spreading wounds, was extracted with diethyl ether. The crude extract, on fractionation by column chromatography (Silica gel) yielded a major solid compound A (mp 210•-212 ° ) crystallizable from acetone-methanol (9:1) into beautiful needle aggregates, the structure of which was identifted, using IR, PMR and MS data, to be that of lupeol, a known antitumor agent. The tumor inhibitory compound Crotopoxide which was previously isolated from the fruits could not be detected in the root­bark extract. Preliminary investigation also showed the presence of trace solids B and C having the same Rf on TLC. B was water isol.uble white solid while C was water soluble and showed strong blue fluorescence under UV-lamp. The presence of quaternary alkaloid was also confirmed in the root-bark.
Description: In Partial Fulfillment of the Requirements for the Degree Master of Science in Chemistry
Appears in Collections:Thesis - Chemistry

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