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Health Related Quality of Life, Predictors and Utility of Cervical Cancer Patients in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

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dc.contributor.advisor Gedif, Teferi (BPharm,MSc, PhD)
dc.contributor.author Teklu, Liya
dc.date.accessioned 2018-11-16T07:59:33Z
dc.date.available 2018-11-16T07:59:33Z
dc.date.issued 2018-09
dc.identifier.uri http://etd.aau.edu.et/handle/123456789/14324
dc.description.abstract Background: Cervical cancer is the second most prevalent malignancy in Ethiopia associated with high mortality and morbidity. It is costly to manage the disease and it severely affects women’s health-related quality of life (HRQOL). Nonetheless, few efforts have been made to assess the patients’ HRQOL, its predictive factors and their utility values set in Ethiopia. As a result, decisions on cost-effective interventions still remains on personal experiences and evidences from other countries, without doing a formal economic Assessment locally. Objective: To validate the Amharic version of European Organization for Research and Treatment of Cancer-Cervical Module (EORTC QLQ-CX24), assess Health Related Quality of Life, its associated factors and utility of cervical cancer patients in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. Methods: An institutional based cross-sectional study was conducted in Tikur Anbessa Specialized Hospital from January to June, 2018. A total of 404 cervical cancer patients were interviewed using the Amharic version of; European Organization for Research and Treatment of Cancer module (EORTC QLQ-C30), EORTC QLQ-CX24 and Euro Quality of Life Group’s 5-Domain Questionnaires 5 Levels (EQ 5D 5L) and Euro Quality of Life Group’s visual scale analog instruments (EQ-VAS) tools. The Amharic versions of all Instruments were previously validated except for the Amharic version of EORTC QLQ-CX24 which was used in the present study through forward and backward translation approach and validated by interviewing 171 cervical cancer patients prior the data collection for the main study. The data was analyzed using SPSS version 23 and Microsoft Office Excel 2010. Pearson correlation, Cronbach's alpha and independent t-test, were employed to assess the reliability and validity of EORTC QLQ-CX24 while; ANOVA and stepwise multivariable logistic regression were employed to determine mean difference and significant associations. Results: The EORTC QLQ-CX24 was found to be acceptable with high compliance and low missing response. The Cronbach’s alpha ranged from 0.70-0.837, indicating reliability of the scale. Convergent and discriminant validity in multi-trait scaling analyses was adequate. The tool also confirmed its clinical validity by differentiating among groups and concurrent validity by the weak to strong correlation with EORTC QLQ-C30. viii In the HRQOL assessment, the mean age of patients was 52.092±0.50 years and majority (93.8%) of the patients were treated as outpatients. The highest proportion (35%) of patients, were on FIGO stage IV of cervical cancer. The Mean ±SD Global quality of life of patients (GQOL) was 48.3 ± 23.77, while the EQ VAS mean score was found to be 65.7 ± 20.83. Social functioning and sexual activity scored the lowest mean from the functioning scales, while financial difficulty, pain and fatigue scored the highest mean from the symptom scales. Physical functioning (AOR=4.98, 95%CI=2.16-11.49), emotional functioning (AOR=5.25, 95%CI=2.2612.17), pain (AOR=5.79, 95%CI=2.30-14.57) and symptom experience (AOR=4.58, 95%CI=1.95-10.79) had a strong association with the GQOL of patients. The utility value was found to be 0.7. Conclusions: Cervical cancer patients reported poor HRQOL and above average utility score. Hence, strong psychological support, pain management and awareness creation including their care takers and partners should be included in the management of this patient group. The Amharic version of the EORTC QLQ-CX24 questionnaire can be used as an acceptable, reliable and efficient tool in clinical use and clinical research to assess the HRQOL of cervical cancer in Ethiopia. en_US
dc.language.iso en_US en_US
dc.publisher Addis Ababa Universty en_US
dc.subject Cancer, Cervical cancer, Validation, Health related quality of life, HRQOL, Utility, EQ5D-5L, EORTC QLQ-C30, EORTCQLQ-CX24, Ethiopia en_US
dc.title Health Related Quality of Life, Predictors and Utility of Cervical Cancer Patients in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia en_US
dc.type Thesis en_US

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