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Serum Level of Inflammatory Markers in Patients with Schizophrenia Attending a Tertiary Service in Addis Ababa, Ethiopia

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dc.contributor.advisor Seifu, Daniel (Associate Professor)
dc.contributor.author Challa, Feyissa
dc.date.accessioned 2018-10-23T09:16:43Z
dc.date.available 2018-10-23T09:16:43Z
dc.date.issued 2016-08
dc.identifier.uri http://localhost:80/xmlui/handle/123456789/13080
dc.description.abstract Introduction: -Accumulating evidence indicates that schizophrenia is accompanied by an activation of the immune/inflammatory system. But there is limited data from low and middleincome countries like Ethiopia. Inflammatory markers may even be more important in these settings where infectious conditions may have more prominent role in the causation and maintenance of schizophrenia. Objective: - To assess the level of inflammatory markers in patients with schizophrenia. Materials and methods - The level of inflammatory markers among patients with schizophrenia were compared with non-affected control groups. The study population consisted of a total 132 study participants, including 82 with schizophrenia and 50 control subjects. High sensitive C-reactive protein (hsCRP) and Interleukin-6(IL-6) were measured using Cobas e 411 and Cobas Intgera 400 Plus analysers at EPHI. Linear regression was used to adjust for confounders in estimating the level of inflammatory markers. The study was conducted from January 2015 to March 2016. Results: - The levels of hsCRP were significantly increased in patients with schizophrenia when compared to control groups (B=; 95% CI=; p=0.003), and also there were significant differences in IL-6 were found in the patients with schizophrenia when compared control groups (B=; 95% CI=; p=0.002).Controlling for age, sex and body mass index, having a diagnostic schizophrenia was the most important factor associated with increased IL-6 and hsCRP. Conclusion: - Higher levels of both hsCRP and IL-6 appear to be associated with schizophrenia, suggesting a role for the inflammatory process in the pathophysiology of schizophrenia. Further investigation using larger sample size are warranted. Clinical trials of interventions to decrease inflammation are worth considering. en_US
dc.language.iso en_US en_US
dc.publisher Addis Ababa Universty en_US
dc.subject schizophrenia, Interleukin-6 (IL-6), high sensitive C - reactive protein (hsCRP) Inflammatory markers, Ethiopia. en_US
dc.title Serum Level of Inflammatory Markers in Patients with Schizophrenia Attending a Tertiary Service in Addis Ababa, Ethiopia en_US
dc.type Thesis en_US

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