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|Title: ||STUDIES ON FIRST ROWTRANSITION METAL COMPLEXES DERIVED FROM NINHYDRIN AND AMINO ACIDS HAVING POLAR(THREONINE) AND NONPOLAR(LEUCINE) SIDE CHAINS|
|Authors: ||Negash, Getachawe|
|Advisors: ||Dr. Yonas Chebude, Advisor|
|Keywords: ||metal complexes, Schiff base, ninhydrin, Ruhmann’s purple, – Leucine, –L–Threonine and antimicrobial activity.|
|Copyright: ||2003 |
|Date Added: ||26-Apr-2008 |
|Publisher: ||Addis Ababa University|
. Complexes of Co(II), Ni(II), and Zn(II) with Ruhmann’s purple, those of Fe(III) and Mn(II) with an
intermediate Schiff base ( ketimine and / or aldimine) and Cu(II) with ninhydrin were successfully
synthesized. All complexes were distinctly colored and stable to atmospheric conditions. The
complexes were characterized by elemental analysis, molar conductance, magnetic susceptibility,
infrared and electronic spectral studies.
The ligands were shown to behave as a monobasic tridentate ONO, bidentate ON or OO donor.
The complexes of Zn(II), Co(II) and Ni(II) are purely Ruhmann’s purple, those of Mn(II) and
Fe(III) are Schiff base (ketimine), Schiff base and ninhydrin or Schiff base and Ruhmann’s purple
complexes. An octahedral geometry is proposed for all of the metal complexes, except Mn(II).
A comparative anti- microbial study of the complexes was undertaken against two gram - negative
bacteria, Escherichia coli and one gram - positive bacterium Staphylococcus aureus. It was
revealed that except Cu(II) and to some extent Zn(II) complexes most of the complexes exhibit a
reduced activity against both bacterium.
KEY WORDS: metal complexes, Schiff base, ninhydrin, Ruhmann’s purple,
– Leucine, –L–Threonine and antimicrobial activity.|
|Description: ||A Thesis Presented to
Office of Research and Graduate Programs
Addis Ababa University
In Partial Fulfillment of the Requirements for the
Degree of Master of Science in Chemistry|
|Appears in:||Thesis - Chemistry|
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