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Addis Ababa University Libraries Electronic Thesis and Dissertations: AAU-ETD! >
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Thesis - Medical Microbiology >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/543
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| Title: | ISOLATION OF MULTI-DRUG RESISTANT ENTEROCOCCI IN PATIENTS AND HEALTH CARE WORKERS IN TIKUR ANBESSA HOSPITAL |
| Authors: | AMARE, WORKU |
| Advisors: | Prof. DP. Monga
Ato Abebe Mache |
| Keywords: | Enterococci
Fecal carriage
Multi-drug resistance
Risk factors
Colonization |
| Copyright: | 2005 |
| Date Added: | 16-Apr-2008 |
| Publisher: | Addis Ababa University |
| Abstract: | The prevalence of fecal colonization by enterococci as well as the antibiotic
susceptibility pattern of multi-drug resistant (MDR) strains is not known in
Ethiopia and a cross sectional study was conducted in a tertiary care multidisciplinary
teaching and national referral hospital in Addis Ababa-Ethiopia
towards this aim. Stool specimens were obtained from 50 outpatients, 50
hospitalized patients, and 50 health-care workers. All speciemens were cultured
on agar media selective to enterococci and isolated strains of Enterococcus
species were tested for antibiogram activity using standard disk diffusion
techniques. About 110 (73.3%) of all study subjects (35/50 outpatient, 39/50
hospitalized patients and 36/50 health-care workers) had enterococci by
phenotypic methods. Among the 110 enterococcal isolates, 17/39 (43.6%) from
hospitalized patients, 8/35 (22.9%) from outpatients, and 7/36 (19.4%) from
health-care workers were found to be multi-drug resistant (resistant to 3 or more
antimicrobial agents used in the study). Ampicilin resistant enterococci (ARE)
were recovered from 41% of hospitalized patients and 14.3% of outpatients.
While 25.6% and 23.1% of isolates from hospitalized patients show High-level
resistance to gentamicin and streptomycin, respectively, carrier rate for High-level
aminoglycoside resistance among outpatients and health-care workers found to be
very low. No vancomycin-resistant enterococci (VRE) were found in this study
although 18.2% of all isolates showed only intermediate susceptibility to
vancomycin. The majority of MDR enterococcal isolates were found to be E.
faecium followed by E. faecalis. Risk factor analysis in this study indicate that
exposure to antimicrobials is the main risk factor for colonization by MDRE and
wiser and restrictive usage of antimicrobials and implementation of policies of
antibiotic usage should have to be considered at a national level. |
| Description: | A THESIS PRESENTED TO GRADUATE STUDIES PROGRAMME, ADDIS ABABA UNIVERSITY IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTERS OF SCIENCE IN MEDICAL ICROBIOLOGY |
| URI: | http://hdl.handle.net/123456789/543 |
| Appears in: | Thesis - Medical Microbiology
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