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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/543

Title: ISOLATION OF MULTI-DRUG RESISTANT ENTEROCOCCI IN PATIENTS AND HEALTH CARE WORKERS IN TIKUR ANBESSA HOSPITAL
Authors: AMARE, WORKU
Advisors: Prof. DP. Monga
Ato Abebe Mache
Keywords: Enterococci
Fecal carriage
Multi-drug resistance
Risk factors
Colonization
Copyright: 2005
Date Added: 16-Apr-2008
Publisher: Addis Ababa University
Abstract: The prevalence of fecal colonization by enterococci as well as the antibiotic susceptibility pattern of multi-drug resistant (MDR) strains is not known in Ethiopia and a cross sectional study was conducted in a tertiary care multidisciplinary teaching and national referral hospital in Addis Ababa-Ethiopia towards this aim. Stool specimens were obtained from 50 outpatients, 50 hospitalized patients, and 50 health-care workers. All speciemens were cultured on agar media selective to enterococci and isolated strains of Enterococcus species were tested for antibiogram activity using standard disk diffusion techniques. About 110 (73.3%) of all study subjects (35/50 outpatient, 39/50 hospitalized patients and 36/50 health-care workers) had enterococci by phenotypic methods. Among the 110 enterococcal isolates, 17/39 (43.6%) from hospitalized patients, 8/35 (22.9%) from outpatients, and 7/36 (19.4%) from health-care workers were found to be multi-drug resistant (resistant to 3 or more antimicrobial agents used in the study). Ampicilin resistant enterococci (ARE) were recovered from 41% of hospitalized patients and 14.3% of outpatients. While 25.6% and 23.1% of isolates from hospitalized patients show High-level resistance to gentamicin and streptomycin, respectively, carrier rate for High-level aminoglycoside resistance among outpatients and health-care workers found to be very low. No vancomycin-resistant enterococci (VRE) were found in this study although 18.2% of all isolates showed only intermediate susceptibility to vancomycin. The majority of MDR enterococcal isolates were found to be E. faecium followed by E. faecalis. Risk factor analysis in this study indicate that exposure to antimicrobials is the main risk factor for colonization by MDRE and wiser and restrictive usage of antimicrobials and implementation of policies of antibiotic usage should have to be considered at a national level.
Description: A THESIS PRESENTED TO GRADUATE STUDIES PROGRAMME, ADDIS ABABA UNIVERSITY IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTERS OF SCIENCE IN MEDICAL ICROBIOLOGY
URI: http://hdl.handle.net/123456789/543
Appears in:Thesis - Medical Microbiology

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