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Title: Simultaneous Determination of paracetamol and para -amino phenol using PEDOT Modified Glassy Carbon Electrode
Authors: Tadele, Hunde
Advisors: Shimelis Admassie(Dr.)
Keywords: Poly (3,4-ethylenedioxythiophene
modified glassy carbon electrode
paracetamol and para-aminophenol
Copyright: Jun-2011
Date Added: 17-Jul-2012
Publisher: Addis Ababa University
Abstract: In this study reliable and simple electrochemical method has been proposed for the simultaneous determination of paracetamol and para-amonophenol in pharmaceutical formulations. The oxidation and reduction peak potentials in of APAP at PEDOT/GC occurred at 381 and 353.65 mV vs. Ag/AgCl, respectively at pH 7.0, while those for PAP at PEDOT/GC appeared at 127 mV and 92 mV, respectively. In comparison to bare glassy carbon, the apparent reversibility and potential shift of the electrochemical reactions of APAP and PAP were significantly improved at PEDOT/GC. A peak separation of about 257.48 mV was observed while running the differential pulse voltammogram of APAP and PAP. This allows for the simultaneous determination of APAP and PAP in tablets. The linear range were found to be 1-100 μM for APAP and 4-320 μM for PAP with the detection limits of 0.4048 μM and 1.1880 μM (calculated by 3σ/m) respectively.
Description: A thesis submitted to school of graduate studies of Addis Ababa University in partial fulfillment of the requirements for the Degree Of Master of Science in Chemistry
URI: http://hdl.handle.net/123456789/3401
Appears in:Thesis - Chemistry

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