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Title: Bioactivity Guided Study on the Antimalarial Activities of Clerodendrum myricoides and Dodonaea angustifolia
Authors: Yemane, Tadesse
Advisors: Yalemtsehay Mekonnen(Prof.)
Keywords: Clerodendrum myricoides
Dodonaea angustifolia
medicinal plants,
Plasmodium berghei
traditional medicine
Copyright: Jun-2011
Date Added: 5-Jul-2012
Publisher: Addis Ababa University
Abstract: Malaria constitutes one of the major health problems in Ethiopia. One of the reasons attributed for the increase was the development of resistance of Plasmodium falciparum to antimalarial drugs. A continued search for other effective, safe and cheap plant-based antimalarial agents thus becomes urgent in the face of these difficulties. The objective of the present study was therefore to evaluate in vivo antiplasmodial activities of successive extracts of Clerodendrum myricoides and Dodonaea angustifolia leaves and possibly isolate active ingredients. They were evaluated for their antimalarial activity in 4-day suppressive assays against Plasmodium berghei strain in Swiss albino mice. The concentrated methanol extract of leaves of C. myricoides and D. angustifolia presented relatively high activities, which reduced the parasitemia by 76.66% and 80.89% at an oral dose of 300mg/kg/day, 76.99% and 78.27% at an oral dose of 500mg/kg/day respectively. On the other hand, the chloroform/ethyl acetate (1:1) and chloroform extracts of these plants did not inhibit the parasitaemia significantly. Ethyl acetate extract obtained from successive extraction of methanol extract of D. angustifolia suppressed parasitaemia significantly (82.24% at 150mg/kg). Similarly the same dose of ethyl acetate and residue (ethyl acetate insoluble) extract of C. myricoides methanol extract also showed moderate inhibition activity with 61.30% and 69.31% mean suppression respectively. The TLC, Column chromatography and NMR spectrometer results of the extracts of these plants indicated that they are rich in natural chemical constituents. The results showed encouraging indications for further refined work on the use of these plants as sources of antimalarial plants.
Description: Thesis Submitted to the School of Graduate Studies in Partial Fulfillment of the Requirements for the Degree of Masters of Science in Biology (Biomedical Science)
URI: http://hdl.handle.net/123456789/3296
Appears in:Thesis - Biology

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