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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/3235

Title: MOLLUSCICIDAL AND CERCARIACIDAL ACTIVITIES OF BALANITES AEGYPTIACA
Authors: Eshetu, Molla
Advisors: Berhanu Erko(Prof.)
Mirutse Giday(Dr.)
Keywords: Balanites aegyptiaca
Biomphalaria pfeifferi
Lymnaea natalensis
aqueous extract
molluscicidal
cercariacidal
schistosomiasis
fascioliasis
Copyright: Jul-2011
Date Added: 30-Jun-2012
Publisher: Addis Ababa University
Abstract: Studies on molluscicidal activity of plants have drawn increasing attention due to such issues as environmental preservation, high cost, and concern over emerging of resistance in snails to synthetic molluscicides. In line with this the present study evaluated the molluscicidal activity of aqueous extracts of Balanites aegyptiaca seeds and fruits against adult Biomphalaria pfeifferi and Lymnaea natalensis snails as well as the cercariacidal activity against Schistosoma mansoni. Snail mortalities were compared between each plant part and snail species, and LC50 and LC90 values for the plant parts tested were computed. For the molluscicidal activities of seed, endocarp, mesocarp and whole fruit part, the LC50 values against B. pfeifferi were 56.32, 77.53, 65.51 and 66.63 ppm, respectively, while the respective LC90 values were 77.70, 120.04, 89.50 and 97.55 ppm. Similarly, the LC50 values for the seed, endocarp, mesocarp and whole fruit against L. natalensis were 80.33, 92.61, 83.52 and 87.84 ppm, respectively, while the respective LC90 values were 102.30, 138.21, 115.42 and 127.69 ppm. B. pfeifferi were found to be more susceptible to B. aegyptiaca than L. natalensis. As regards the cercariacidal activities of the plant, the in vitro mortality of cercariae exposed to aqueous extract of seeds increased with increasing concentration and exposure time. Infectivity evaluation test showed that S. mansoni cercariae exposed to 15 ppm of aqueous extract of seeds were incapable of infecting mice. In particular, the mean egg load of tissue was reduced in mice infected with the cercariae exposed to 5 and 10 ppm (ANOVA, p<0.05). In conclusion, the aqueous extracts of B. aegyptiaca have reasonable molluscicidal and cercariacidal activities. Yet, comprehensive laboratory evaluation of this plant is required before its field use.
Description: A Thesis Submitted to the School of Graduate Studies of Addis Ababa University In Partial Fulfillment of the Requirements for the Degree of Master of Science in Biology (Biomedical Science)
URI: http://hdl.handle.net/123456789/3235
Appears in:Thesis - Biology

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