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Addis Ababa University Libraries Electronic Thesis and Dissertations: AAU-ETD! >
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Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/3105
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| Title: | Bioassay Guided Phytochemical Investigation on Roots of Taverniera Abyssinica (Dingetegna) |
| Authors: | Mekuriaw, Assefa |
| Advisors: | Ermias Dagne (Professor) |
| Keywords: | Phytochemical Investigation
Taverniera Abyssinica |
| Copyright: | Jul-2010 |
| Date Added: | 21-May-2012 |
| Publisher: | ADDIS ABABA UNIVERSITY |
| Abstract: | The chemical constituents in EtOAc extract of the Ethiopian traditional medicinal plant
‘Dingetegna”, Taverniera abyssinica, were reinvestigated and the claimed antispasmodic activity
of them were examined. The chemical constituents were isolated and purified by various
chromatographic methods and their structures were elucidated mainly by NMR. The two
compounds isolated were identified as 3-hydroxy-9-methoxypterocarpan, a known compound
called medicarpin and 3,4-dihydroxypterocarpan (4-hydroxymedicarpin). Both compounds
antagonized the histamine induced contraction of guinea pig ileum. Medicarpin was more active
than its natural derivative 4-hydroxymedicarpin. |
| URI: | http://hdl.handle.net/123456789/3105 |
| Appears in: | Thesis - Chemistry
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