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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/3105

Title: Bioassay Guided Phytochemical Investigation on Roots of Taverniera Abyssinica (Dingetegna)
Authors: Mekuriaw, Assefa
Advisors: Ermias Dagne (Professor)
Keywords: Phytochemical Investigation
Taverniera Abyssinica
Copyright: Jul-2010
Date Added: 21-May-2012
Abstract: The chemical constituents in EtOAc extract of the Ethiopian traditional medicinal plant ‘Dingetegna”, Taverniera abyssinica, were reinvestigated and the claimed antispasmodic activity of them were examined. The chemical constituents were isolated and purified by various chromatographic methods and their structures were elucidated mainly by NMR. The two compounds isolated were identified as 3-hydroxy-9-methoxypterocarpan, a known compound called medicarpin and 3,4-dihydroxypterocarpan (4-hydroxymedicarpin). Both compounds antagonized the histamine induced contraction of guinea pig ileum. Medicarpin was more active than its natural derivative 4-hydroxymedicarpin.
URI: http://hdl.handle.net/123456789/3105
Appears in:Thesis - Chemistry

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