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|Title: ||The involvement of Adiponectin Type 2 Diabetessystematic review of findings on human|
|Authors: ||SOFTWARE DEVELOPMENT FOR HYDROLOGIC ANALYSIS AND HYDRAULIC DESIGN OF MINOR HIGHWAY DRAINAGE, STRUCTURES|
|Advisors: ||Daniel Seifu (PhD)|
type 2 diabetes
|Copyright: ||Jun-2011 |
|Date Added: ||16-May-2012 |
|Publisher: ||ADDIS ABABA UNIVERSITY|
|Abstract: ||Background: The association of obesity with development of type 2 diabetes may be
partly mediated by altered secretion of adipokines by adipose tissue. Greater adiposity
down regulates secretion of adiponectin, an adipokine with anti-inflammatory and insulin
sensitizing properties. The strength and consistency of the relation between plasma
adiponectin and risk of type 2 diabetes is unclear.
Objective: To review prospective studies of the involvement of adiponectin in type
Methods: A review search of the pub med, hinari and Google scholar search engine
using different name of adiponectin and type 2 diabetes mellitus. This systemic review
included prospective studies with plasma adiponectin levels as the exposure and
incidence of type 2 diabetes.
Results: Ten prospective studies with a total of 7018 participants and 1343 incident
cases of type2 diabetes were included in the review. Higher adiponectin levels were
monotonically associated with a lower risk of type 2 diabetes. This inverse association
was consistently observed in whites, Middle East Asians, East Asians, Asian Indians,
African Americans, Japan Americans and Native Americans and the inverse relationships
are not differ by adiponectin assay, method of diabetes ascertainment, duration of followup.
Conclusion: Higher adiponectin levels are associated with a lower risk of type 2 diabetes
across diverse populations.|
|Appears in:||Thesis - Biochemistry |
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