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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/3073

Title: The involvement of Adiponectin Type 2 Diabetessystematic review of findings on human
Authors: SOFTWARE DEVELOPMENT FOR HYDROLOGIC ANALYSIS AND HYDRAULIC DESIGN OF MINOR HIGHWAY DRAINAGE, STRUCTURES
Advisors: Daniel Seifu (PhD)
Keywords: adiponectin
adipose tissue
type 2 diabetes
Copyright: Jun-2011
Date Added: 16-May-2012
Publisher: ADDIS ABABA UNIVERSITY
Abstract: Background: The association of obesity with development of type 2 diabetes may be partly mediated by altered secretion of adipokines by adipose tissue. Greater adiposity down regulates secretion of adiponectin, an adipokine with anti-inflammatory and insulin sensitizing properties. The strength and consistency of the relation between plasma adiponectin and risk of type 2 diabetes is unclear. Objective: To review prospective studies of the involvement of adiponectin in type 2diabetes. Methods: A review search of the pub med, hinari and Google scholar search engine using different name of adiponectin and type 2 diabetes mellitus. This systemic review included prospective studies with plasma adiponectin levels as the exposure and incidence of type 2 diabetes. Results: Ten prospective studies with a total of 7018 participants and 1343 incident cases of type2 diabetes were included in the review. Higher adiponectin levels were monotonically associated with a lower risk of type 2 diabetes. This inverse association was consistently observed in whites, Middle East Asians, East Asians, Asian Indians, African Americans, Japan Americans and Native Americans and the inverse relationships are not differ by adiponectin assay, method of diabetes ascertainment, duration of followup. Conclusion: Higher adiponectin levels are associated with a lower risk of type 2 diabetes across diverse populations.
URI: http://hdl.handle.net/123456789/3073
Appears in:Thesis - Biochemistry

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