AAU-ETD AAU-ETD
 

Addis Ababa University Libraries Electronic Thesis and Dissertations: AAU-ETD! >
College of Social Science >
Thesis - Archaeology >

Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/304

Title: STUDIES ON METAL COMPLEXES DERIVED FROM PHYSIOLOGICALLY ACTIVE QUINOXALINE DERIVATIVES
Authors: Gojje, Gamo
Advisors: Prof. Nigussie Retta
Prof. V.J.T. Raju
Dr. Yonas Chebude
Keywords: Quinoxaline
o-phenyldiamine
salicylaldehyde
hydrazine
2,3-quinoxalinedione (QXD)
2,3-quinoxalinedioxime (QXDO)
2,3-dichloroquinoxaline (DCQX)
Copyright: 2006
Date Added: 3-Dec-2007
Publisher: Addis Ababa University
Abstract: Coordination compounds, with bonds between a central metal atom and surrounding ligands, play critical roles in biology, biochemistry and medicine, controlling the structure and function of many enzymes and their metabolism. They play similarly vital roles in many industrial processes and in the development of new materials with specifically designed properties. Thus synthesis and study of such complexes is very important. In this lab work, equimolar quantities of o-phenyldiamine and oxalic acid dihydrate were condensed in 5N HCl under reflux to 2,3-quinoxalinedione. Refluxing of 2,3-quinoxalinedione with phosphorus (V) chloride as well as with thionylchloride gave 2,3 dichloroquinoxaline which was then treated first with hydroxylamine hydrochloride to afford a new ligand 2,3- quinoxalinedioxime (QXDO) and secondly with N-(aminoformimidoyl)phenol to give quinoxaline-2,3-bis-[N-(aminoformimidoyl)phenol] (QXAP) both of which contain nitrogen and oxygen donor atoms. However, the formation of QXAP was unsuccessful as it was confirmed by 1H NMR. Thus QXDO was further complexed with divalent metal salts to give different complexes. New metal complexes of nickel and copper with quinoxalinedioxime (QXDO) were prepared. The complexes were characterized by elemental analysis, conductance measurements, atomic absorption, IR, NMR and UV spectroscopy and magnetic moments. QXDO behaves as a bidetate ligand.
Description: Graduate Project Chem.774 Submitted to the School of Graduate Studies Addis Ababa University In Partial Fulfillment of the Requirements for the Degree of Master of Science in Chemistry
URI: http://hdl.handle.net/123456789/304
Appears in:Thesis - Chemistry

Files in This Item:

File Description SizeFormat
Gojje Gamo.pdf786.6 kBAdobe PDFView/Open

Items in the AAUL Digital Library are protected by copyright, with all rights reserved, unless otherwise indicated.

 

  Last updated: May 2010. Copyright © Addis Ababa University Libraries - Feedback